Gusel' V A, Smirnov D P
Farmakol Toksikol. 1980 Jul-Aug;43(4):431-3.
In spite of the appearance of the tolerance to phenibut in white rats at days 11-12 of its intraperitoneal administration (250 mg/kg), the drug injections (25 micrograms) into the lateral ventricles of the brain via permanent cannulas evoked, as before, a fall in the body temperature and synchronization of the electrocorticogram in rats. The tolerance to phenibut did not occur when the drug was injected daily (12 days) into the brain ventricles. A conclusion is made that the tolerance to phenibut has a peripheral character.
尽管在腹腔注射苯乙胺（250毫克/千克）第11 - 12天时，大白鼠出现了对苯乙胺的耐受性，但通过永久性套管向大鼠脑侧脑室注射该药物（25微克），仍如之前一样引起体温下降和脑电图同步。当每天（12天）向脑室注射该药物时，未出现对苯乙胺的耐受性。得出结论，对苯乙胺的耐受性具有外周性质。
