在阿尔茨海默型老年痴呆症患者的颞叶皮质中，免疫反应性生长抑素含量减少。
Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type.
作者信息
Rossor M N, Emson P C, Mountjoy C Q, Roth M, Iversen L L
出版信息
Neurosci Lett. 1980 Dec;20(3):373-7. doi: 10.1016/0304-3940(80)90177-9.
Post-mortem brain tissue from 15 patients dying with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 16 control patients at routine post-mortem. A significant fall in choline acetyltransferase (ChAT) activity was observed in the cortex, hippocampus and amygdala of the SDAT cases and was maximal in the temporal cortex. The fall in ChAT activity observed in the temporal cortex was accompanied by a significant reduction (47%) in immunoreactive somatostatin.
将15例诊断为阿尔茨海默型老年痴呆症（SDAT）死亡患者的尸检脑组织与16例对照患者在常规尸检时获得的组织进行比较。在SDAT病例的皮质、海马体和杏仁核中观察到胆碱乙酰转移酶（ChAT）活性显著下降，在颞叶皮质中下降最为明显。在颞叶皮质中观察到的ChAT活性下降伴随着免疫反应性生长抑素显著减少（47%）。
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