阿尔茨海默型老年痴呆症患者大脑皮质中胆碱乙酰转移酶活性降低，但血管活性肠肽并未发生变化。
Reduced cortical choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide.
作者信息
Rossor M, Fahrenkrug J, Emson P, Mountjoy C, Iversen L, Roth M
出版信息
Brain Res. 1980 Nov 10;201(1):249-53. doi: 10.1016/0006-8993(80)90795-7.
Post-mortem brain tissue from 7 patients who died with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 7 control patients at routine post mortem. A significant fall in choline acetyltransferase (ChAT) activity was apparent in the cerebral cortex of the SDAT cases which was maximal in the temporal lobe. The fall in ChAT activity was not accompanied by changes in cortical vasoactive intestinal polypeptide (VIP) measured by radioimmunoassay.
将7例诊断为阿尔茨海默型老年性痴呆（SDAT）死亡患者的尸检脑组织与7例对照患者常规尸检获得的组织进行比较。SDAT病例的大脑皮质中胆碱乙酰转移酶（ChAT）活性明显下降，在颞叶最为显著。ChAT活性的下降并未伴随通过放射免疫测定法测得的皮质血管活性肠肽（VIP）的变化。
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