• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿尔茨海默型老年痴呆症患者大脑皮质中胆碱乙酰转移酶活性降低，但血管活性肠肽并未发生变化。

Reduced cortical choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide.

作者信息

Rossor M, Fahrenkrug J, Emson P, Mountjoy C, Iversen L, Roth M

出版信息

Brain Res. 1980 Nov 10;201(1):249-53. doi: 10.1016/0006-8993(80)90795-7.

DOI:10.1016/0006-8993(80)90795-7
PMID:7417838
Abstract

Post-mortem brain tissue from 7 patients who died with a diagnosis of senile dementia of Alzheimer type (SDAT) was compared with tissue obtained from 7 control patients at routine post mortem. A significant fall in choline acetyltransferase (ChAT) activity was apparent in the cerebral cortex of the SDAT cases which was maximal in the temporal lobe. The fall in ChAT activity was not accompanied by changes in cortical vasoactive intestinal polypeptide (VIP) measured by radioimmunoassay.

摘要

将7例诊断为阿尔茨海默型老年性痴呆（SDAT）死亡患者的尸检脑组织与7例对照患者常规尸检获得的组织进行比较。SDAT病例的大脑皮质中胆碱乙酰转移酶（ChAT）活性明显下降，在颞叶最为显著。ChAT活性的下降并未伴随通过放射免疫测定法测得的皮质血管活性肠肽（VIP）的变化。

相似文献

1
Reduced cortical choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide.阿尔茨海默型老年痴呆症患者大脑皮质中胆碱乙酰转移酶活性降低，但血管活性肠肽并未发生变化。
Brain Res. 1980 Nov 10;201(1):249-53. doi: 10.1016/0006-8993(80)90795-7.
2
Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients.非神经疾病患者及阿尔茨海默型老年痴呆症患者新皮层、海马体和基底前脑中的胆碱能酶。
Brain Res. 1983 May 16;267(2):281-91. doi: 10.1016/0006-8993(83)90880-6.
3
Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type.在阿尔茨海默型老年痴呆症患者的颞叶皮质中，免疫反应性生长抑素含量减少。
Neurosci Lett. 1980 Dec;20(3):373-7. doi: 10.1016/0304-3940(80)90177-9.
4
Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls.阿尔茨海默病患者及对照者大脑中胆碱乙酰转移酶免疫组化研究
Neurosci Lett. 1983 Apr 11;36(2):195-9. doi: 10.1016/0304-3940(83)90264-1.
5
Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type.阿尔茨海默病及阿尔茨海默型老年痴呆症病例中的皮质生长抑素样免疫反应性
Neurobiol Aging. 1981 Spring;2(1):9-14. doi: 10.1016/0197-4580(81)90053-1.
6
The substantia innominata in Alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes.阿尔茨海默病中的无名质：胆碱能标记酶的组织化学和生物化学研究
Neurosci Lett. 1982 Feb 12;28(2):217-22. doi: 10.1016/0304-3940(82)90155-0.
7
VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer's disease/senile dementia of the Alzheimer type.在受阿尔茨海默病/阿尔茨海默型老年痴呆症影响的脑组织中的血管活性肠肽敏感腺苷酸环化酶、鸟苷酸环化酶、毒蕈碱受体、胆碱乙酰转移酶和乙酰胆碱酯酶。
Neurobiol Aging. 1988 Mar-Apr;9(2):153-62. doi: 10.1016/s0197-4580(88)80045-9.
8
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.老年痴呆症中的神经递质酶异常。尸检脑组织中的胆碱乙酰转移酶和谷氨酸脱羧酶活性。
J Neurol Sci. 1977 Nov;34(2):247-65. doi: 10.1016/0022-510x(77)90073-9.
9
A post-mortem study of the cholinergic and GABA systems in senile dementia.老年痴呆症中胆碱能和γ-氨基丁酸系统的尸检研究。
Brain. 1982 Jun;105(Pt 2):313-30. doi: 10.1093/brain/105.2.313.
10
Somatostatin and vasoactive intestinal polypeptide in postmortem brains from patients with Alzheimer-type dementia.阿尔茨海默病型痴呆患者尸检大脑中的生长抑素和血管活性肠肽
Neurosci Lett. 1984 Nov 23;52(1-2):73-8. doi: 10.1016/0304-3940(84)90353-7.

引用本文的文献

1
Alterations in neuropeptides in aging and disease. Pathophysiology and potential for clinical intervention.衰老与疾病中神经肽的改变。病理生理学及临床干预潜力。
Drugs Aging. 1993 Sep-Oct;3(5):408-27. doi: 10.2165/00002512-199303050-00003.
2
Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies.阿尔茨海默病受累皮质区域中高亲和力胆碱转运体的过表达。来自快速尸检研究的证据。
J Clin Invest. 1994 Aug;94(2):696-702. doi: 10.1172/JCI117387.
3
Confusion, dementia and anticholinergics in Parkinson's disease.
帕金森病中的认知障碍、痴呆与抗胆碱能药物
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1161-4. doi: 10.1136/jnnp.45.12.1161.
4
Is the loss of cerebral cortical choline acetyl transferase activity in Alzheimer's disease due to degeneration of ascending cholinergic nerve cells.阿尔茨海默病中大脑皮质胆碱乙酰转移酶活性的丧失是由于上行胆碱能神经细胞的退化所致吗？
J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):936. doi: 10.1136/jnnp.45.10.936.
5
The noradrenergic system in Alzheimer and multi-infarct dementias.阿尔茨海默病和多发性梗死性痴呆中的去甲肾上腺素能系统。
J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):113-9. doi: 10.1136/jnnp.45.2.113.
6
Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core.帕金森病和阿尔茨海默病作为等树突核心的疾病。
Br Med J (Clin Res Ed). 1981 Dec 12;283(6306):1588-90. doi: 10.1136/bmj.283.6306.1588.
7
Cortical vasoactive intestinal peptide in relation to dementia in Parkinson's disease.帕金森病中与痴呆相关的皮质血管活性肠肽
J Neurol Neurosurg Psychiatry. 1985 Aug;48(8):842-3. doi: 10.1136/jnnp.48.8.842.
8
Reduction of arginine-vasopressin in the cerebral cortex in Alzheimer type senile dementia.阿尔茨海默型老年痴呆症患者大脑皮质中精氨酸加压素的减少。
J Neurol Neurosurg Psychiatry. 1987 Jul;50(7):929-32. doi: 10.1136/jnnp.50.7.929.
9
Alzheimer's disease and senile dementia: biochemical characteristics and aspects of treatment.阿尔茨海默病与老年痴呆症：生化特征及治疗方面
Psychopharmacology (Berl). 1985;86(3):245-52. doi: 10.1007/BF00432208.
10
Comparison of DSIP- (delta sleep-inducing peptide) and P-DSIP-like (phosphorylated) immunoreactivity in cerebrospinal fluid of patients with senile dementia of Alzheimer type, multi-infarct syndrome, communicating hydrocephalus and Parkinson's disease.阿尔茨海默型老年痴呆症、多发性梗死综合征、交通性脑积水及帕金森病患者脑脊液中促睡眠肽（DSIP，δ睡眠诱导肽）和类磷酸化促睡眠肽（P-DSIP）免疫反应性的比较
J Neurol. 1987 Oct;235(1):16-21. doi: 10.1007/BF00314191.