Pharmacokinetic aspects of anxiolytic drug therapy.
作者信息
Greenblatt D J, Shader R I
出版信息
Can J Neurol Sci. 1980 Aug;7(3):269-70. doi: 10.1017/s0317167100023349.
PMID:6108797
Abstract
Benzodiazepine derivatives are neuropharmacologically similar but may appear clinically distinct due to pharmacokinetic differences. The clinical effects of single doses depend mainly on rates of drug absorption and distribution, whereas drug accumulation is a major determinant of clinical action during multiple dosage. This paper outlines potential clinical implications of benzodiazepine pharmacokinetics.
摘要
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