von der Hardt H, Menger W
Monatsschr Kinderheilkd. 1980 Dec;128(12):766-9.
In a group of 40 asthmatic children, the following lung function parameters were measured during symptom free period: functional residual capacity (FRC); vital capacity (VC); total lung capacity (TLC); total pulmonary flow resistance (R1) and dynamic lung compliance (C1dyn). All the children were examined during their stay on Norderney (an island in the North Sea). The mean values of all measured lung volumes were significantly larger than the predicted values (p < 0.001), the mean value of R1 corresponded to the predicted one whereas the mean value of C1dyn was significantly smaller (p < 0.001), most of the individual values being within the normal range. After inhalation of Orciprenaline the mean value of R1 was significantly smaller than the initial value (about 15%; p < 0.001), whereas the lung volumes as well as C1 dyn were still unchanged. The influence of Orciprenaline on R1 and was only temporary and was reproducible 24 h later. Ther low mean value of C1 cyn was independent of the length of stay on Norderney. The reasons for this phenomena are discussed: obstructions and/or occlusions in the smallest airways seem to be the most important factor, uninfluenced by beta-2-mimetic drugs.
在一组40名哮喘儿童中，在无症状期测量了以下肺功能参数：功能残气量（FRC）；肺活量（VC）；肺总量（TLC）；总肺流阻（R1）和动态肺顺应性（C1dyn）。所有儿童均在其于诺德尼岛（北海中的一个岛屿）停留期间接受了检查。所有测量肺容积的平均值均显著高于预测值（p<0.001），R1的平均值与预测值相符，而C1dyn的平均值显著较小（p<0.001），大多数个体值在正常范围内。吸入奥西那林后，R1的平均值显著小于初始值（约15%；p<0.001），而肺容积以及C1dyn仍无变化。奥西那林对R1的影响只是暂时的，并且在24小时后可重现。C1dyn的低平均值与在诺德尼岛停留的时间长短无关。文中讨论了这种现象的原因：最小气道中的阻塞和/或闭塞似乎是最重要的因素，不受β2-拟交感神经药物影响。
