去甲氯氮卓对神经症和精神病住院患者焦虑状态的精神镇静作用。

The psychosedative effect of chlordesmethyldiazepam on anxiety states in neurotic and psychotic inpatients.

作者信息

Paradiso L, Rapisarda V

出版信息

Clin Ther. 1980;3(3):194-9.

Abstract

A new benzodiazepine, chlordesmethyldiazepam, was administered at a dose of 6 mg/day to 27 patients (18 neurotics and 9 psychotics) with the common symptom of anxiety. The study period was limited to eight days for the whole group, although the drug has been given to some patients for 38 days. Changes in global scores in neurotic patients were determined by administering the Wittenborn and Hamilton rating scales. In psychotic patients the same rating scales were used in addition to the BPRS. A multistimulator was used to evaluate the performance recording complex reaction times (CRT). The statistical evaluation of results shows a highly significant amelioration of all the studied parameters except for reaction times in the psychotic group.

摘要

一种新的苯二氮䓬类药物——去甲氯氮卓，以每日6毫克的剂量给予27例有焦虑这一常见症状的患者（18例神经症患者和9例精神病患者）。尽管该药物已给予部分患者长达38天，但整个组的研究期限定为8天。通过使用维滕伯恩和汉密尔顿评定量表来确定神经症患者总体评分的变化。在精神病患者中，除了使用这些评定量表外，还使用简明精神病评定量表（BPRS）。使用多刺激器评估表现，记录复合反应时间（CRT）。结果的统计评估显示，除了精神病组的反应时间外，所有研究参数均有高度显著的改善。