Sinniah D, Baskaran G
Lancet. 1981 Feb 28;1(8218):487-9. doi: 10.1016/s0140-6736(81)91861-4.
Vomiting, drowsiness, metabolic acidosis, polymorphonuclear leucocytosis, and encephalopathy developed in thirteen infants within hours of ingestion of margosa oil. Liver biopsy of one infant and necropsy examination of ICR strain mice after experimentally induced margosa-oil poisoning demonstrated pronounced fatty infiltration of the liver and proximal renal tubules as well as cerebral oedema. Electron microscopy demonstrated mitochondrial damage. These findings indicate that margosa oil may be involved in the aetiology of Reye's syndrome among Indians in Malaysia.
13名婴儿在摄入苦楝油数小时内出现呕吐、嗜睡、代谢性酸中毒、多形核白细胞增多和脑病。对1名婴儿进行肝活检，并对实验性诱导苦楝油中毒后的ICR品系小鼠进行尸检，结果显示肝脏和近端肾小管有明显的脂肪浸润以及脑水肿。电子显微镜检查显示线粒体损伤。这些发现表明，苦楝油可能与马来西亚印度人患瑞氏综合征的病因有关。
