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一例因食用印楝油继发中毒性视神经病变的罕见病例。

A rare case of toxic optic neuropathy secondary to consumption of neem oil.

作者信息

Suresha A R, Rajesh P, Anil Raj K S, Torgal Radhika

机构信息

Department of Ophthalmology, J. J. M. Medical College, Davangere, Karnataka, India.

出版信息

Indian J Ophthalmol. 2014 Mar;62(3):337-9. doi: 10.4103/0301-4738.121129.

DOI:10.4103/0301-4738.121129
PMID:24722271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4061674/
Abstract

A 35-year-old female was referred to our hospital with bilateral loss of vision of two days duration. She gave history of consumption of about 150 ml of neem oil five days back.Examination revealed no perception of light in both eyes. Both pupils were dilated and sluggishly reacting to light. Her fundus examination showed bilateral hyperemic, edematous discs and also edema extending along the superior and inferior temporal vascular arcade. Magnetic resonance imaging (MRI) scan showed bilateral putaminal regions with altered signal, hypointensities in T1-weighted images, hyperintensities on T2-weighted, images and hyperintense on Fluid Attenuation Inversion Recovery (FLAIR) images suggestive of cytotoxic edema due to tissue hypoxia. Her vision improved to 20/200 in both eyes with treatment after two months. This is the first case report of such nature in the literature to the best of our knowledge.

摘要

一名35岁女性因双眼视力丧失两天被转诊至我院。她自述五天前饮用了约150毫升印楝油。检查发现双眼无光感。双侧瞳孔散大,对光反应迟钝。眼底检查显示双侧视盘充血、水肿,且水肿沿颞侧上下血管弓延伸。磁共振成像(MRI)扫描显示双侧壳核区域信号改变,T1加权图像呈低信号,T2加权图像呈高信号,液体衰减反转恢复(FLAIR)图像呈高信号,提示因组织缺氧导致细胞毒性水肿。经过两个月的治疗,她双眼视力恢复到20/200。据我们所知,这是文献中首例此类病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/642c3a43036f/IJO-62-337-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/3a8fea07754a/IJO-62-337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/cbc4c3139942/IJO-62-337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/0826c6029a20/IJO-62-337-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/2fd5896fc084/IJO-62-337-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/16a37f3f1a3b/IJO-62-337-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/642c3a43036f/IJO-62-337-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/3a8fea07754a/IJO-62-337-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/cbc4c3139942/IJO-62-337-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/0826c6029a20/IJO-62-337-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/2fd5896fc084/IJO-62-337-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/16a37f3f1a3b/IJO-62-337-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f564/4061674/642c3a43036f/IJO-62-337-g006.jpg

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