Weiss E, Avtalion R R
Dev Comp Immunol. 1977 Apr;1(2):93-103. doi: 10.1016/s0145-305x(77)80003-7.
Enhancement of primary anti-hapten antibody response was more efficient when carp were preimmunized with modified carrier, rather than with its native form, especially when they were challenged with a slightly substituted penicilloyl-BSA conjugate (Pen5 BSA). No significant enhancement was obtained when the fish were challenged with a heavy conjugate (Pen30 BSA). When fish kept at optimal temperature were preinjected with the modified carriers, rising titers of anti-hapten antibodies were obtained even when the fish were transferred to low temperature just before being challenged with Pen5 BSA. It was concluded that modified carriers are more efficient in enhancing the anti-hapten antibody response and light conjugates are needed to make the cell cooperation possible. It was also suggested that when helper memory cell maturation was allowed to develop at optimal conditions, both cell cooperation and antibody synthesis could occur at low temperatures.
当鲤鱼用修饰后的载体而非天然形式的载体进行预免疫时，对初级抗半抗原抗体反应的增强更为有效，尤其是当它们受到轻微取代的青霉酰 - BSA 偶联物（Pen5 BSA）攻击时。当用重偶联物（Pen30 BSA）攻击鱼时，未获得显著增强效果。当处于最佳温度的鱼预先注射修饰后的载体时，即使在鱼即将受到 Pen5 BSA 攻击之前转移到低温环境下，也能获得抗半抗原抗体滴度的升高。得出的结论是，修饰后的载体在增强抗半抗原抗体反应方面更有效，并且需要轻偶联物来实现细胞协同作用。还表明，当辅助记忆细胞在最佳条件下成熟时，细胞协同作用和抗体合成在低温下都可能发生。
