Charney D S, Nelson J C
Am J Psychiatry. 1981 Mar;138(3):328-33. doi: 10.1176/ajp.138.3.328.
In a retrospective analysis, the course, symptoms, treatment response, and personality of 54 delusional and 66 nondelusional unipolar depressed patients were compared. The delusional patients had more guilt feelings and were more ruminative, agitated, and referential than the nondelusional patients. They had a poor response to a tricyclic antidepressant therapy but good treatment outcome with a tricyclic-antipsychotic combination or ECT. The form and content of prior episodes were remarkably similar to the index episode in both groups. The authors believe that these findings support the conception of unipolar delusional depression as a distinct subtype of depressive illness.
在一项回顾性分析中，对54例妄想性和66例非妄想性单相抑郁患者的病程、症状、治疗反应及人格进行了比较。与非妄想性患者相比，妄想性患者有更多的内疚感，且更爱沉思、易激惹并有牵连观念。他们对三环类抗抑郁药治疗反应不佳，但对三环类抗抑郁药与抗精神病药联合治疗或电休克治疗有良好的治疗效果。两组既往发作的形式和内容与本次发作显著相似。作者认为，这些发现支持将单相妄想性抑郁视为抑郁性疾病的一种独特亚型这一概念。
