Little H J, Rees J M
J Pharm Pharmacol. 1980 Nov;32(11):751-6. doi: 10.1111/j.2042-7158.1980.tb13060.x.
The actions of 2-aminoindane, 2-amino-1,2,3,4-tetrahydronaphthalene and amphetamine and their N-methyl and NN-dimethyl derivatives on the guinea-pig ileum were compared. All, except the tertiary 2-aminoindane, inhibited the responses to electrical stimulation and it is suggested that this is not fully explained by their sympathomimetic properties. NN-Diemthyl-2-aminoindane increased these responses and caused contractions of the unstimulated ileum due to a nicotine-like action. The indane series was more effective in producing contractions of the ileum than the other compounds. The three tertiary derivatives antagonized competitively the actions of histamine on the ileum and those of 5-hydroxy-tryptamine on the rat uterus.
比较了2-氨基茚满、2-氨基-1,2,3,4-四氢萘、苯丙胺及其N-甲基和N,N-二甲基衍生物对豚鼠回肠的作用。除叔2-氨基茚满外，所有化合物均抑制对电刺激的反应，提示这不能完全用它们的拟交感神经特性来解释。N,N-二甲基-2-氨基茚满增强这些反应，并因类似烟碱的作用导致未受刺激的回肠收缩。茚满系列在引起回肠收缩方面比其他化合物更有效。三种叔衍生物竞争性拮抗组胺对回肠和5-羟色胺对大鼠子宫的作用。
