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Br J Pharmacol. 1969 Mar;35(3):383-93. doi: 10.1111/j.1476-5381.1969.tb08280.x.
2
ACTION OF DEXAMPHETAMINE ON 5-HYDROXYTRYPTAMINE RECEPTORS.右旋苯丙胺对5-羟色胺受体的作用。
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3
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4
Effects of 5-hydroxytryptamine on isolated strips of the guinea-pig stomach.5-羟色胺对豚鼠胃离体肌条的作用。
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Distribution and types of adrenoceptors in the guinea-pig ileum: the action of alpha- and beta-adrenoceptor blocking agents.豚鼠回肠中肾上腺素能受体的分布及类型：α和β肾上腺素能受体阻断剂的作用
Br J Pharmacol. 1982 Aug;76(4):569-78. doi: 10.1111/j.1476-5381.1982.tb09256.x.
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本文引用的文献

1
The action of some amines related to adrenaline: methoxy-phenylisopropylamines.一些与肾上腺素相关的胺类的作用：甲氧基苯异丙胺。
J Physiol. 1939 May 15;95(4):485-500. doi: 10.1113/jphysiol.1939.sp003745.
2
THE ACTION OF MORPHINE-LIKE DRUGS ON IMPULSE TRANSMISSION IN MAMMALIAN NERVE FIBRES.吗啡类药物对哺乳动物神经纤维冲动传导的作用
Br J Pharmacol Chemother. 1964 Jun;22(3):499-510. doi: 10.1111/j.1476-5381.1964.tb01704.x.
3
ACTION OF DEXAMPHETAMINE ON 5-HYDROXYTRYPTAMINE RECEPTORS.右旋苯丙胺对5-羟色胺受体的作用。
Br J Pharmacol Chemother. 1963 Dec;21(3):427-35. doi: 10.1111/j.1476-5381.1963.tb02010.x.
4
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.5-羟色胺受体在豚鼠离体回肠肌间神经丛上的位点
Br J Pharmacol Chemother. 1963 Oct;21(2):306-22. doi: 10.1111/j.1476-5381.1963.tb01529.x.
5
An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum.药物对离体豚鼠回肠的直接和间接作用分析。
Br J Pharmacol Chemother. 1963 Feb;20(1):150-70. doi: 10.1111/j.1476-5381.1963.tb01306.x.
6
The action of drugs on the circular muscle strip from the guinea-pig isolated ileum.药物对豚鼠离体回肠环形肌条的作用。
Br J Pharmacol Chemother. 1963 Jun;20(3):399-417. doi: 10.1111/j.1476-5381.1963.tb01478.x.
7
Andrenergic receptive mechanism of canine ileum.犬回肠的肾上腺素能受体机制。
J Pharmacol Exp Ther. 1959 Oct;127:146-9.
8
A sensitive method for the assay of 5-hydroxytryptamine.一种测定5-羟色胺的灵敏方法。
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
9
Two kinds of tryptamine receptor.两种色胺受体。
Br J Pharmacol Chemother. 1957 Sep;12(3):323-8. doi: 10.1111/j.1476-5381.1957.tb00142.x.
10
The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.吗啡及相关物质对同轴刺激的豚鼠回肠收缩和乙酰胆碱释放的作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x.

拟交感胺对肠道5-羟色胺受体的兴奋作用。

Excitatory action of sympathomimetic amines on 5-hydroxytryptamine receptors of gut.

作者信息

Innes I R, Kohli J D

出版信息

Br J Pharmacol. 1969 Mar;35(3):383-93. doi: 10.1111/j.1476-5381.1969.tb08280.x.

DOI:10.1111/j.1476-5381.1969.tb08280.x
PMID:5809731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703370/
Abstract
  1. Twenty-two sympathomimetic amines were tested for excitatory activity on isolated guinea-pig ileum, rabbit jejunum, and rat stomach.2. Eight amines contracted all or almost all guinea-pig ileum preparations; five amines contracted half the preparations and relaxed the others. Nine amines were consistently relaxant. Structural requirements for excitatory activity were not clear.3. Six amines contracted rat stomach and only four contracted rabbit jejunum. Only beta-phenylethylamine and (-)-amphetamine contracted all three preparations.4. The excitatory effects of the sympathomimetic amines on guinea-pig ileum seem to be due to an action on 5-hydroxytryptamine receptors. This conclusion is based on evidence that their excitatory action is antagonized by 2-bromolysergic acid diethylamide, by morphine and by desensitization with 5-hydroxytryptamine, and that there is cross-protection between 5-hydroxytryptamine and the excitatory sympathomimetic amines against block by phenoxybenzamine.
摘要

  1. 对22种拟交感胺进行了测试，观察它们对豚鼠离体回肠、兔空肠和大鼠胃的兴奋活性。

  2. 8种胺使所有或几乎所有豚鼠回肠标本收缩；5种胺使一半标本收缩，另一半松弛。9种胺始终表现为松弛作用。兴奋活性的结构要求尚不明确。

  3. 6种胺使大鼠胃收缩，只有4种使兔空肠收缩。只有β-苯乙胺和（-）-苯丙胺使所有三种标本收缩。

  4. 拟交感胺对豚鼠回肠的兴奋作用似乎是由于作用于5-羟色胺受体。这一结论基于以下证据：它们的兴奋作用被2-溴麦角酸二乙酰胺、吗啡以及5-羟色胺脱敏所拮抗，并且5-羟色胺与兴奋性拟交感胺之间存在针对苯氧苄胺阻断的交叉保护作用。