[3H]西咪替丁与大鼠脑组织的结合
Binding of [3H]cimetidine to rat brain tissue.
作者信息
Smith I R, Cleverley M T, Ganellin C R, Metters K M
出版信息
Agents Actions. 1980 Nov;10(5):422-6. doi: 10.1007/BF01968040.
PMID:6111196
Abstract
Binding of [3H]cimetidine to rat brain tissue was investigated, and a saturable binding with dissociation constant 0.22 +/- 0.05 microM found. This binding is inhibited by a range of imidazole-derived histamine H2-receptor antagonists, but not by a number of non-imidazole H2-receptor antagonists. It is concluded that the [3H]cimetidine binding site in rat brain tissue that is labelled in these experiments is not the histamine H2-receptor.
摘要
研究了[3H]西咪替丁与大鼠脑组织的结合情况，发现存在解离常数为0.22±0.05微摩尔的饱和结合。这种结合受到一系列咪唑衍生的组胺H2受体拮抗剂的抑制，但不受多种非咪唑H2受体拮抗剂的抑制。得出的结论是，在这些实验中标记的大鼠脑组织中的[3H]西咪替丁结合位点不是组胺H2受体。
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