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病毒抗体在多发性硬化症发病机制中的作用研究。

Investigation on the role of viral antibodies in the pathogenesis of multiple sclerosis.

作者信息

Matveeva T V, Pille E R, Diakonova I N, Andreeva A P

出版信息

Acta Virol. 1980 Dec;24(6):415-20.

PMID:6111202
Abstract

An attempt was made to elucidate the role of antibodies to measles, rubella and mumps viruses in the pathogenesis of multiple sclerosis by correlating their levels in the blood of patients with clinical manifestations of the disease. Antibody titres to measles and rubella viruses were higher during exacerbations of the process and decreased during remissions. No correlation was found between the level of viral antibodies and the duration of the disease, features of its course (rapidly or slowly progressing), or the phase of the disease. The rise of viral antibody titres in multiple sclerosis appears to be a secondary process not associated with the disease aetiologically and playing no role in its pathogenesis.

摘要

通过将患有多发性硬化症患者血液中的抗体水平与该疾病的临床表现相关联,试图阐明抗麻疹、风疹和腮腺炎病毒抗体在多发性硬化症发病机制中的作用。在疾病发作期间,抗麻疹和风疹病毒的抗体滴度较高,而在缓解期则降低。未发现病毒抗体水平与疾病持续时间、病程特征(进展迅速或缓慢)或疾病阶段之间存在相关性。多发性硬化症中病毒抗体滴度的升高似乎是一个继发过程,在病因学上与该疾病无关,并且在其发病机制中不起作用。

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1
Investigation on the role of viral antibodies in the pathogenesis of multiple sclerosis.病毒抗体在多发性硬化症发病机制中的作用研究。
Acta Virol. 1980 Dec;24(6):415-20.
2
Possible role of measles, rubella and mumps viruses in multiple sclerosis.麻疹、风疹和腮腺炎病毒在多发性硬化症中的潜在作用。
Acta Virol. 1977 Mar;21(2):139-45.
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[Clinical immunological studies of disseminated sclerosis].[播散性硬化症的临床免疫学研究]
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Viral and bacterial antibody responses in multiple sclerosis.多发性硬化症中的病毒和细菌抗体反应。
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Virus antibodies in patients with multiple sclerosis.多发性硬化症患者体内的病毒抗体。
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Rubella susceptibility predicts measles susceptibility: implications for postpartum immunization.风疹易感性可预测麻疹易感性:对产后免疫的启示。
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引用本文的文献

1
Viral antibodies in multiple sclerosis.多发性硬化症中的病毒抗体。
Ital J Neurol Sci. 1982 Jul;3(2):115-8. doi: 10.1007/BF02043942.