Bonard M, de Almeida S, von Niederhäusern W
Eur Urol. 1976;2(1):24-8. doi: 10.1159/000471953.
A double placebo-controlled study using the anti-androgen non-steroidal compound Flutamide in 32 patients with benign enlargement of the prostate is reported. A statistical analysis of the results showed no difference between the group treated with Flutamide and the group receiving the placebo, except in as far as 'the size' of the prostate was concerned. We observed a significant reduction of the latter in patients receiving Flutamide. The different problems produced by the choice and the measure of parameters in this type of investigation have been discussed.
本文报道了一项双盲安慰剂对照研究，该研究对32例前列腺良性增生患者使用了抗雄激素非甾体化合物氟他胺。结果的统计分析表明，除了前列腺“大小”方面，服用氟他胺的组和接受安慰剂的组之间没有差异。我们观察到接受氟他胺治疗的患者前列腺大小显著减小。本文还讨论了这类研究中参数选择和测量所产生的不同问题。
