Syrkin A B, Smirnova I O, Lazarev N I
Arzneimittelforschung. 1977 Jul;27(7):1467-9.
A study was carried out in 146 common rats to assess the effects of 4'-nitro-3'-trifluoromethylisobutyranilide (Sch 13521) on the hypertrophied prostate gland. The hypertrophy was induced in castrated, sexually immature males by s.c. implantation of a pill of testosterone-propionate. After 20 days of administration of Sch 13521 in oral doses of 5, 10 and 25 mg/kg, the dimensions and weight of the hypertrophied prostate gland were reduced by 1.5 to 2 times. After 2 months of administration of the preparation in doses of 10 and 25 mg/kg a reduction of the hypertrophied prostate gland to the dimensions of the intact control was observed. Morphological studies confirmed the efficacy of the therapeutic action of Sch 13521.
对146只普通大鼠进行了一项研究，以评估4'-硝基-3'-三氟甲基异丁酰苯胺（Sch 13521）对前列腺肥大的影响。通过皮下植入丙酸睾酮丸剂，在去势的、性未成熟的雄性大鼠中诱导前列腺肥大。以5、10和25mg/kg的口服剂量给予Sch 13521 20天后，前列腺肥大的尺寸和重量减少了1.5至2倍。以10和25mg/kg的剂量给予该制剂2个月后，观察到前列腺肥大缩小至完整对照的尺寸。形态学研究证实了Sch 13521治疗作用的有效性。
