Indices of alcohol intake. Comparison between serum concentrations of alkaline phosphatase and gamma glutamyltransferase in middle-aged men.

A comparison was performed on the validity of serum-gamma-glutamyltransferase (S-GT) and serum-alkaline phosphatase (S-ALP) concentrations for establishing the increased alcohol intake in a group of middle-aged men in Uppsala. These men were all born in 1915 and were participants of a special health investigation performed at their age of 60 years. Subjects who were registered at the Temperance Board, or had ethyl alcohol in urine or gave a positive reply to a question of alcohol intake were designated alcohol index cases. The mean S-GT values of these different alcohol index groups were significantly higher than that of a randomly selected subgroup devoid of alcohol findings in the same population. No such differences were found when comparing the corresponding mean S-ALP values. The authors thus point to the superiority of S-GT determinations to S-ALP determinations, especially in patients where the alcohol consumption certainly not is to be regarded as excessive.