抗组胺药、局部麻醉药及其他胺类作为抗病毒剂。
Antihistaminics, local anesthetics, and other amines as antiviral agents.
作者信息
Miller D K, Lenard J
出版信息
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3605-9. doi: 10.1073/pnas.78.6.3605.
Abstract
A number of lipophilic amines of diverse chemical structure, including antihistaminics, local anesthetics, and chloroquine, were found to exhibit similar kinetics in inhibiting the infection of BHK cells by vesicular stomatitis virus. The inhibition occurred prior to both primary and secondary RNA transcription but following transfer from the cell surface to an intracellular site, presumed to be the lysosomes. A similar inhibition, by these agents, of infection by Sendai, influenza strain WSN, and Semliki Forest viruses suggested a lysosomal involvement in infection by these viruses as well.
摘要
人们发现，许多化学结构各异的亲脂性胺类，包括抗组胺药、局部麻醉药和氯喹，在抑制水泡性口炎病毒感染BHK细胞方面表现出相似的动力学。这种抑制作用发生在初级和次级RNA转录之前，但在病毒从细胞表面转移到细胞内位点（推测为溶酶体）之后。这些药物对仙台病毒、流感WSN株病毒和Semliki森林病毒感染的类似抑制作用表明，溶酶体也参与了这些病毒的感染过程。
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