糖酵解酶（醛缩酶、异构酶和丙酮酸激酶）夺取质子的化学过程。

Chemistry of proton abstraction by glycolytic enzymes (aldolase, isomerases and pyruvate kinase).

作者信息

Rose I A

出版信息

Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):131-43. doi: 10.1098/rstb.1981.0067.

DOI:10.1098/rstb.1981.0067

Abstract

Intermediates have been synthesized that are rapidly utilized by triose phosphate isomerase, yeast aldolase and pyruvate kinase. In each case the compounds have the properties of an enol expected for a stepwise proton transfer mechanism. Apparently the apparatus required for doing this chemistry is sufficiently unique for a large measure of structural homology to have been imposed upon the enzymes of this class during evolution.

摘要

已经合成了一些中间体，它们能被磷酸丙糖异构酶、酵母醛缩酶和丙酮酸激酶快速利用。在每种情况下，这些化合物都具有烯醇的性质，这是逐步质子转移机制所预期的。显然，进行这种化学反应所需的机制足够独特，以至于在进化过程中，这类酶在很大程度上具有结构同源性。