Kambara T, Yasaka T, Nakamura T
Virchows Arch B Cell Pathol Incl Mol Pathol. 1981;37(2):191-8. doi: 10.1007/BF02892567.
Rabbit antisera (APS) against normal guinea pig peritoneal exudate polymorphonuclear leukocytes (PMN), when injected intraperitoneally three times within 24 h into guinea pigs, lead to a marked fall in the blood PMN count (below 100/mm3) 24-72 h after the injection and a mild depression in the number of circulating mononuclear leukocytes (MNC) at 36-72 h. APS treatment of guinea pigs led to a marked suppression of delayed hypersensitivity skin reactions in response to dinitrophenylated bovine gamma-globulin. The volume, induration, mean diameter of the reaction and leukocyte (both PMN and MNC) emigration into local sites were suppressed, as was, to a lesser extent, vascular permeability. Based on these observations it appears that circulating PMN are required for the full expression of delayed hypersensitivity reaction engendered by bovine gamma-globulin.
针对正常豚鼠腹腔渗出多形核白细胞（PMN）的兔抗血清（APS），在24小时内对豚鼠进行三次腹腔注射后，注射后24至72小时血液中的PMN计数显著下降（低于100/mm³），36至72小时循环单核白细胞（MNC）数量出现轻度减少。对豚鼠进行APS处理导致对二硝基苯基化牛γ球蛋白的迟发型超敏皮肤反应受到显著抑制。反应的体积、硬结、平均直径以及白细胞（PMN和MNC）向局部部位的迁移均受到抑制，血管通透性也在较小程度上受到抑制。基于这些观察结果，似乎循环中的PMN对于牛γ球蛋白引发的迟发型超敏反应的充分表达是必需的。
