Artemova A G
Zh Mikrobiol Epidemiol Immunobiol. 1979 Dec(12):63-7.
Experiments in delayed type hypersensitivity transfer were carried out with the aim of studying the ability of rabbit antisera against peritoneal exudate cells of rats sensitized with bovine gamma globulin or rabbit kidney tissue antigen to block peritoneal exudate cells of guinea pigs. In the serological test the antisera prepared against the cells of sensitized rats and tentatively named "receptor antisera", reacted not only with the cells of these rats, respectively, but also with guinea pig cells. In hypersensitivity transfer experiments in guinea pigs receptor antisera showed a blocking effect on the transferred cells, making them incapable of transferring hypersensitivity, i. e. rabbit antisera against rat peritoneal exudate cells reacted with guinea pig cells. This interaction was specific: the blocking effect was manifested only when guinea pigs whose cells were used in the transfer were sensitized with the same antigen as the rats against whose cells the receptor antisera had been prepared. The control antisera, taken for the treatment of the transferred cells in the same doses as the receptor antisera, had no blocking effect on the cells.
进行迟发型超敏反应转移实验的目的是研究兔抗血清对豚鼠腹腔渗出细胞的阻断能力，该抗血清是针对用牛γ球蛋白或兔肾组织抗原致敏的大鼠腹腔渗出细胞制备的。在血清学试验中，针对致敏大鼠细胞制备的抗血清（暂称为“受体抗血清”）不仅分别与这些大鼠的细胞发生反应，还与豚鼠细胞发生反应。在豚鼠的超敏反应转移实验中，受体抗血清对转移的细胞表现出阻断作用，使其无法转移超敏反应，即兔抗大鼠腹腔渗出细胞抗血清与豚鼠细胞发生反应。这种相互作用是特异性的：只有当用于转移的豚鼠细胞与制备受体抗血清所针对的大鼠细胞用相同抗原致敏时，才会表现出阻断作用。以与受体抗血清相同剂量用于处理转移细胞的对照抗血清，对细胞没有阻断作用。
