四种不同β-肾上腺素能受体阻断药物对淋巴细胞异丙肾上腺素刺激的环磷酸腺苷生成的比较。
Comparison of four different beta-adrenoceptor blocking drugs on lymphocyte isoprenaline-stimulated cyclic AMP production.
作者信息
Lima D R, Kilfeather S, Hedges A, Turner P
出版信息
Br J Clin Pharmacol. 1981 Jun;11(6):555-9. doi: 10.1111/j.1365-2125.1981.tb01170.x.
Abstract
1 The influence of acebutolol, atenolol, pindolol and timolol on human lymphocyte cyclic AMP (cAMP) and its stimulation by isoprenaline in vitro has been studied. 2 Acebutolol and atenolol (10(-8)-10(-6)M) had no significant influence on lymphocyte cAMP levels or on isoprenaline-stimulated increase in cAMP. 3 Pindolol and timolol significantly antagonised the effect of isoprenaline, and pA2 values were calculated to be 8.12 and 8.04 respectively. This suggests that beta 2-adrenoceptors are involved in this phenomenon. 4 Only pindolol produced a significant increase in lymphocyte cAMP, which is consistent with its partial agonist activity.
摘要
已研究了醋丁洛尔、阿替洛尔、吲哚洛尔和噻吗洛尔对人淋巴细胞环磷酸腺苷（cAMP）的影响及其在体外对异丙肾上腺素刺激cAMP的作用。
醋丁洛尔和阿替洛尔（10⁻⁸ - 10⁻⁶M）对淋巴细胞cAMP水平或异丙肾上腺素刺激的cAMP增加无显著影响。
吲哚洛尔和噻吗洛尔显著拮抗异丙肾上腺素的作用，计算出的pA2值分别为8.12和8.04。这表明β₂肾上腺素能受体参与了这一现象。
仅吲哚洛尔使淋巴细胞cAMP显著增加，这与其部分激动剂活性一致。
相似文献
1
Comparison of four different beta-adrenoceptor blocking drugs on lymphocyte isoprenaline-stimulated cyclic AMP production.四种不同β-肾上腺素能受体阻断药物对淋巴细胞异丙肾上腺素刺激的环磷酸腺苷生成的比较。
Br J Clin Pharmacol. 1981 Jun;11(6):555-9. doi: 10.1111/j.1365-2125.1981.tb01170.x.
2
Cardiac and bronchial beta-adrenoceptor antagonistic potencies of atenolol, metoprolol, acebutolol, practolol, propranolol and pindolol in the anaesthetized dog.阿替洛尔、美托洛尔、醋丁洛尔、普拉洛尔、普萘洛尔和吲哚洛尔对麻醉犬心脏和支气管β-肾上腺素能受体的拮抗作用强度
Clin Exp Pharmacol Physiol. 1978 Jan-Feb;5(1):53-9. doi: 10.1111/j.1440-1681.1978.tb00651.x.
3
Beta-adrenoceptor antagonists (non-selective as well as beta 1-selective) with partial agonistic activity decrease beta 2-adrenoceptor density in human lymphocytes. Evidence for a beta 2-agonistic component of the partial agonistic activity.具有部分激动活性的β-肾上腺素受体拮抗剂（非选择性以及β1选择性）可降低人淋巴细胞中的β2-肾上腺素受体密度。部分激动活性中β2激动成分的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):130-8. doi: 10.1007/BF00506515.
4
Hemodynamic and beta-adrenergic receptor adaptations during long-term beta-adrenoceptor blockade. Studies with acebutolol, atenolol, pindolol, and propranolol in hypertensive patients.长期β-肾上腺素能受体阻断期间的血流动力学和β-肾上腺素能受体适应性变化。在高血压患者中使用醋丁洛尔、阿替洛尔、吲哚洛尔和普萘洛尔的研究。
Circulation. 1989 Oct;80(4):903-14. doi: 10.1161/01.cir.80.4.903.
5
Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors.（-）-吲哚洛尔的内在拟交感活性通过人心房和重组受体中β1-肾上腺素能受体的（-）-普萘洛尔耐药位点介导。
Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):496-503. doi: 10.1007/s00210-003-0835-z. Epub 2003 Nov 8.
6
Blockade of isoprenaline-induced changes in plasma free fatty acids, immunoreactive insulin levels and plasma renin activity in healthy human subjects, by propranolol, pindolol, practolol, atenolol, metoprolol and acebutolol.普萘洛尔、吲哚洛尔、醋氨心安、阿替洛尔、美托洛尔和醋丁洛尔对健康人体受试者中异丙肾上腺素诱导的血浆游离脂肪酸、免疫反应性胰岛素水平和血浆肾素活性变化的阻断作用。
Br J Clin Pharmacol. 1978 Jan;5(1):19-26. doi: 10.1111/j.1365-2125.1978.tb01593.x.
7
Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen.特布他林诱导的人淋巴细胞β2 -肾上腺素能受体脱敏。泼尼松和酮替芬加速β -肾上腺素能受体反应性的恢复。
J Clin Invest. 1985 Sep;76(3):1096-101. doi: 10.1172/JCI112063.
8
Electrophysiological effects of cardioselective and non-cardioselective beta-adrenoceptor blockers with and without ISA at rest and during exercise.具有和不具有内在拟交感活性的心脏选择性和非心脏选择性β-肾上腺素受体阻滞剂在静息和运动时的电生理效应。
Br J Clin Pharmacol. 1982;13(Suppl 2):285S-293S. doi: 10.1111/j.1365-2125.1982.tb01926.x.
9
beta(2) and beta(3)-adrenoceptor inhibition of alpha(1)-adrenoceptor-stimulated Ca(2+) elevation in human cultured prostatic stromal cells.β₂和β₃肾上腺素能受体对人培养前列腺基质细胞中α₁肾上腺素能受体刺激的Ca²⁺升高的抑制作用。
Eur J Pharmacol. 2007 Sep 10;570(1-3):18-26. doi: 10.1016/j.ejphar.2007.05.035. Epub 2007 Jun 5.
10
Beta-adrenoceptors in human alveolar macrophages isolated by elutriation.通过淘洗法分离的人肺泡巨噬细胞中的β-肾上腺素能受体。
Br J Clin Pharmacol. 1990 Nov;30(5):673-82. doi: 10.1111/j.1365-2125.1990.tb03835.x.
引用本文的文献
1
Influence of intravenous beta-adrenergic blockade with or without partial agonist activity upon plasma cyclic AMP and catecholamines in healthy subjects.静脉注射具有或不具有部分激动剂活性的β-肾上腺素能阻滞剂对健康受试者血浆环磷酸腺苷和儿茶酚胺的影响。
Eur J Clin Pharmacol. 1984;26(6):695-8. doi: 10.1007/BF00541927.
2
Pindolol--a beta-adrenoceptor blocking drug with partial agonist activity: clinical pharmacological considerations.吲哚洛尔——一种具有部分激动剂活性的β-肾上腺素能受体阻滞剂：临床药理学考量
Br J Clin Pharmacol. 1982;13(Suppl 2):187S-192S. doi: 10.1111/j.1365-2125.1982.tb01909.x.
3
Ethnic differences in human lymphocytic cyclic AMP production after isoprenaline stimulation and propranolol blockade.异丙肾上腺素刺激和普萘洛尔阻断后人类淋巴细胞环磷酸腺苷产生的种族差异。
Br J Clin Pharmacol. 1985 Feb;19(2):187-90. doi: 10.1111/j.1365-2125.1985.tb02630.x.
4
Effects of three beta-blockers with different pharmacodynamic properties on platelet aggregation and platelet and plasma cyclic AMP.三种具有不同药效学特性的β受体阻滞剂对血小板聚集以及血小板和血浆环磷酸腺苷的影响。
Eur J Clin Pharmacol. 1988;35(1):17-20. doi: 10.1007/BF00555501.
本文引用的文献
1
Beta-adrenoceptors in human lung, bronchus and lymphocytes.人肺、支气管及淋巴细胞中的β-肾上腺素能受体。
Br J Clin Pharmacol. 1980 Nov;10(5):425-32. doi: 10.1111/j.1365-2125.1980.tb01783.x.
2
Comparison of a new beta adrenergic blocker (MK 950) and propranolol in man.新型β肾上腺素能阻滞剂（MK 950）与普萘洛尔在人体中的比较。
Clin Pharmacol Ther. 1972 Mar-Apr;13(2):232-8. doi: 10.1002/cpt1972132232.
3
A potent beta-adrenoreceptor blocking drug: 4-(2-hydroxy-3-isopropylaminopropoxy)indole.一种强效β-肾上腺素能受体阻断药物：4-(2-羟基-3-异丙氨基丙氧基)吲哚。
J Pharm Pharmacol. 1970 Mar;22(3):180-8. doi: 10.1111/j.2042-7158.1970.tb08494.x.
4
Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides.环核苷酸的放射免疫测定。I. 抗体及碘化环核苷酸的制备。
J Biol Chem. 1972 Feb 25;247(4):1106-13.
5
Timolol maleate, a new beta-adrenergic receptor blocking agent.马来酸噻吗洛尔，一种新型β-肾上腺素能受体阻滞剂。
Arch Int Pharmacodyn Ther. 1975 Feb;213(2):251-63.
6
The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockade in hypertension, past, present and future.第二届礼来奖讲座，纽卡斯尔大学，1977年7月。高血压中的β-肾上腺素能受体阻断：过去、现在与未来。
Br J Clin Pharmacol. 1978 May;5(5):379-99. doi: 10.1111/j.1365-2125.1978.tb01644.x.
7
The assessment of beta-adrenoceptor blocking drugs in man.人体中β-肾上腺素能受体阻断药物的评估。
Br J Clin Pharmacol. 1977 Aug;4(4):413-25. doi: 10.1111/j.1365-2125.1977.tb00756.x.
8
The selective action of beta-adrenoceptor blocking drugs and the nature of beta1 and beta2 adrenoceptors.β-肾上腺素能受体阻断药的选择性作用及β1和β2肾上腺素能受体的性质。
Br J Pharmacol. 1977 Jan;59(1):83-93. doi: 10.1111/j.1476-5381.1977.tb06980.x.
9
The beta-adrenoceptor of the human lymphocyte and human lung parenchyma.人类淋巴细胞和人类肺实质的β-肾上腺素能受体。
Br J Pharmacol. 1977 Jan;59(1):17-23. doi: 10.1111/j.1476-5381.1977.tb06971.x.
Zotero 插件