人类淋巴细胞和人类肺实质的β-肾上腺素能受体。
The beta-adrenoceptor of the human lymphocyte and human lung parenchyma.
作者信息
Conolly M E, Greenacre J K
出版信息
Br J Pharmacol. 1977 Jan;59(1):17-23. doi: 10.1111/j.1476-5381.1977.tb06971.x.
Abstract
1 The response of the beta-adrenoceptors of human lymphocytes to selective agonists and antagonists has been studied quantitatively by measuring changes in cyclic adenosine-3',5'-monophosphate (cyclic AMP) levels. 2 The receptor was activated by isoprenaline and by salbutamol, and blocked by propranolol but not by practolol. A similar pattern of response was obtained with fragments of human lung tissue. 3 The mean value for pA2 for propranolol was 8.34 and for practolol was 3.95. 4 These findings indicate that the lymphocyte beta-adrenoceptor is a beta2-receptor and support the solidity of using lymphocytes to study beta-adrenoceptor function in bronchial asthma. It may also be of use in the evaluation of selective beta2-blocking drugs in man.
摘要
1 通过测量环磷腺苷（环磷酸腺苷）水平的变化，对人淋巴细胞β肾上腺素能受体对选择性激动剂和拮抗剂的反应进行了定量研究。2 该受体可被异丙肾上腺素和沙丁胺醇激活，并被普萘洛尔阻断，但不被普拉洛尔阻断。用人肺组织碎片也得到了类似的反应模式。3 普萘洛尔的pA2平均值为8.34，普拉洛尔的pA2平均值为3.95。4 这些发现表明淋巴细胞β肾上腺素能受体是β2受体，并支持利用淋巴细胞研究支气管哮喘中β肾上腺素能受体功能的可靠性。它也可能有助于评估人体内的选择性β2受体阻滞剂。
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