同时应用D-（-）-果糖对D-半乳糖胺诱导的肝细胞损伤模式的影响。
The pattern of D-galactosamine-induced hepatocellular injury modified by simultaneous application of D (--)-fructose.
作者信息
Rumpelt H J, Bode C
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1981;36(2-3):235-45. doi: 10.1007/BF02912069.
As shown by light and electron microscopy, and by biochemical investigation, D-galactosamine-induced hepatocellular injury in the rat can be prevented by giving fructose simultaneously. However, when injected 3 h after D-galactosamine, fructose has no protective effect. It is suggested that rapid fructose phosphorylation, with the consequent marked depression of the hepatocellular ATP pool, inhibits the more prolonged D-galactosamine phosphorylation and with it the injurious effects of D-galactosamine metabolism.
光学显微镜、电子显微镜检查以及生化研究结果表明，同时给予果糖可预防D-半乳糖胺诱导的大鼠肝细胞损伤。然而，在给予D-半乳糖胺3小时后注射果糖，则没有保护作用。有人提出，果糖的快速磷酸化会导致肝细胞ATP池显著降低，从而抑制D-半乳糖胺更持久的磷酸化及其代谢产生的有害作用。
Zotero 插件