Camanni E, Strumia E, Portaleone P, Molinatti G M
Eur J Clin Pharmacol. 1981;20(5):347-9. doi: 10.1007/BF00615404.
In 20 mild hypertensive women, reserpine induced a significant increase in mean plasma PRL, both under basal conditions (from 6.6 +/- 0.9 to 17.9 +/- 2.9 ng/ml), and on repeated determinations during the day. In contrast to reserpine, the administration of syrosingopine, a synthetic compound derived from reserpine, to the same subjects was not followed by a significant change in prolactin level. Beyond their pharmacological interest, these results are of clinical importance when considering that rauwolfia alkaloids are used for long term treatment, and that an increase in PRL levels is important in pathology, both in relation to the function of the hypophyseogonadal axis and in view of its possible facilitation of the growth and development of mammary cancer.
在20名轻度高血压女性中，利血平在基础状态下（从6.6±0.9 ng/ml升至17.9±2.9 ng/ml）以及在一天中的多次测定中均导致平均血浆催乳素显著升高。与利血平相反，给同一组受试者施用从利血平衍生而来的合成化合物辛可宁，催乳素水平并未出现显著变化。除了其药理学意义外，鉴于萝芙木生物碱用于长期治疗，并且催乳素水平升高在病理学中很重要，无论是与垂体性腺轴的功能有关，还是考虑到其可能促进乳腺癌的生长和发展，这些结果都具有临床重要性。
