Lee P A, Kelly M R, Wallin J D
JAMA. 1976 May 24;235(21):2316-7.
Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P less than .005). This association between regular, long-term reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.
与停用利血平治疗六周后的水平相比,接受利血平治疗的高血压患者血清催乳素水平显著更高(P小于0.005)。长期规律使用利血平与更高的催乳素水平之间的这种关联可能具有临床意义,因为据报道,接受利血平治疗的高血压患者中乳腺癌发病率有所增加。