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利血平治疗高血压患者期间催乳素水平升高。

Increased prolactin levels during reserpine treatment of hypertensive patients.

作者信息

Lee P A, Kelly M R, Wallin J D

出版信息

JAMA. 1976 May 24;235(21):2316-7.

PMID:131202
Abstract

Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P less than .005). This association between regular, long-term reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.

摘要

与停用利血平治疗六周后的水平相比,接受利血平治疗的高血压患者血清催乳素水平显著更高(P小于0.005)。长期规律使用利血平与更高的催乳素水平之间的这种关联可能具有临床意义,因为据报道,接受利血平治疗的高血压患者中乳腺癌发病率有所增加。

相似文献

1
Increased prolactin levels during reserpine treatment of hypertensive patients.利血平治疗高血压患者期间催乳素水平升高。
JAMA. 1976 May 24;235(21):2316-7.
2
Effect of reserpine on serum prolactin, growth hormone, and glucocorticoids in dairy cows.利血平对奶牛血清催乳素、生长激素和糖皮质激素的影响。
Proc Soc Exp Biol Med. 1977 Jun;155(2):189-92. doi: 10.3181/00379727-155-39771.
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Effect of prolactin on adrenocortical and gonadal function in normal men.催乳素对正常男性肾上腺皮质及性腺功能的影响。
J Clin Endocrinol Metab. 1977 Apr;44(4):760-2. doi: 10.1210/jcem-44-4-760.
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Hormonal changes following hypophysectomy in humans.人类垂体切除术后的激素变化。
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Effects of reserpine on prolactin levels and incidence of breast cancer in postmenopausal women.利血平对绝经后女性催乳素水平及乳腺癌发病率的影响。
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Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy.接受氨鲁米特治疗的晚期乳腺癌患者复发相关的内分泌变化。
J Clin Endocrinol Metab. 1984 Jan;58(1):99-104. doi: 10.1210/jcem-58-1-99.
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Prolactin secretion during reserpine and syrosingopine treatment.利血平和蛇根亭宁治疗期间的催乳素分泌。
Eur J Clin Pharmacol. 1981;20(5):347-9. doi: 10.1007/BF00615404.
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Puberty in girls: correlation of serum levels of gonadotropins, prolactin, androgens, estrogens, and progestins with physical changes.女孩青春期:促性腺激素、催乳素、雄激素、雌激素和孕激素血清水平与身体变化的相关性
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J Clin Endocrinol Metab. 1991 May;72(5):1025-30. doi: 10.1210/jcem-72-5-1025.

引用本文的文献

1
Pharmacological causes of hyperprolactinemia.高泌乳素血症的药理学病因。
Ther Clin Risk Manag. 2007 Oct;3(5):929-51.
2
Drugs and prolactin.药物与催乳素
Pituitary. 2008;11(2):209-18. doi: 10.1007/s11102-008-0106-6.
3
Reserpine, hydrochlorothiazide and pituitary-gonadal hormones in hypertensive patients.
Eur J Clin Pharmacol. 1980 May;17(5):329-32. doi: 10.1007/BF00558444.
4
Adverse effects of antihypertensive drugs.抗高血压药物的不良反应。
Drugs. 1981 Sep;22(3):188-210. doi: 10.2165/00003495-198122030-00002.
5
Effects of antihypertensive drugs on endocrine function.抗高血压药物对内分泌功能的影响。
Drugs. 1984 May;27(5):447-58. doi: 10.2165/00003495-198427050-00004.
6
Prolactin secretion during reserpine and syrosingopine treatment.利血平和蛇根亭宁治疗期间的催乳素分泌。
Eur J Clin Pharmacol. 1981;20(5):347-9. doi: 10.1007/BF00615404.
7
Frequency of benign and malignant breast lesions in 207 consecutive autopsies in Australian women.
Br J Cancer. 1985 Feb;51(2):271-8. doi: 10.1038/bjc.1985.39.
8
Drug-induced changes in prolactin secretion. Clinical implications.药物引起的催乳素分泌变化。临床意义。
Med Toxicol Adverse Drug Exp. 1988 Nov-Dec;3(6):463-98. doi: 10.1007/BF03259897.