Jensen S, Hüttel M S, Schou Olesen A
Br J Anaesth. 1981 Oct;53(10):1083-5. doi: 10.1093/bja/53.10.1083.
Local venous reactions during and after the injection i.v. of diazepam in oil (Diazemuls) and the water-soluble benzodiazepine midazolam (Dormicum) were studied in 100 patients undergoing gastroscopy. Observation time was 2 weeks. Of the patients receiving diazepam in oil, 8% experienced pain on injection and 6% subsequently developed clinical evidence of thrombophlebitis. Corresponding figures for midazolam were 6% and 10% respectively. No significant differences were observed between the effects of the two drugs.
对100例接受胃镜检查的患者进行了研究,观察静脉注射油性地西泮(安定乳剂)和水溶性苯二氮䓬咪达唑仑(多美康)期间及之后的局部静脉反应。观察时间为2周。接受油性地西泮的患者中,8%在注射时出现疼痛,6%随后出现血栓性静脉炎的临床证据。咪达唑仑的相应数字分别为6%和10%。两种药物的效果之间未观察到显著差异。