Schou Olesen A, Hüttel M S
Br J Anaesth. 1980 Jun;52(6):609-11. doi: 10.1093/bja/52.6.609.
Local venous reactions during and after i.v injections of three different formulations of diazepam were studied in 200 patients undergoing gastroscopy. Of the patients receiving diazepam in propylene glycol (Stesolid) 78% experienced pain on injection and 48% subsequently developed clinical evidence of thrombophlebitis. The figures for Stesolid MR (diazepam in Cremophor EL) were 38% and 9% respectively. A significant decrease was achieved (pain on injection 1%; clinical thrombophlebitis 4%) when using Diazemuls, a new formulation in which diazepam is dissolved in oil and emulsified in water. Since no difference in the therapeutic effect of the different formulations was observed, Diazemuls represents a clear advantage to Stesolid and Stesolid MR.
在200例接受胃镜检查的患者中，研究了静脉注射三种不同剂型地西泮期间及之后的局部静脉反应。接受丙二醇剂型地西泮（安定注射液）的患者中，78%在注射时感到疼痛，48%随后出现血栓性静脉炎的临床证据。安定乳剂（聚氧乙烯蓖麻油剂型地西泮）的相应数字分别为38%和9%。使用一种新剂型得普利麻（地西泮溶于油中并乳化于水中）时，有显著下降（注射时疼痛1%；临床血栓性静脉炎4%）。由于未观察到不同剂型在治疗效果上的差异，得普利麻相对于安定注射液和安定乳剂具有明显优势。
