Graham C W, Pagano R R, Conner J T
Anaesthesia. 1978 Feb;33(2):188-91. doi: 10.1111/j.1365-2044.1978.tb08348.x.
Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis. This was improved when diazepam, 10 mg, was diluted to 20-40 ml with intravenous solution. In contrast, lorazepam appeared to have minimal irritative or injurious effects on veins whether undiluted or diluted. In view of these results and clinical studies reporting a higher patient acceptance of lorazepam than diazepam, lorazepam may be a superior drug for use in anaesthesia.
接受未稀释地西泮的手术患者中有87%在注射时感到疼痛，而6%-16%（取决于剂量）出现临床血栓性静脉炎的迹象。当将10毫克地西泮用静脉溶液稀释至20-40毫升时，这种情况得到改善。相比之下，劳拉西泮无论未稀释还是稀释，似乎对静脉的刺激性或损伤性都最小。鉴于这些结果以及临床研究报告显示患者对劳拉西泮的接受度高于地西泮，劳拉西泮可能是一种更适合用于麻醉的药物。
