Val'dman A V, Kozlovskaia M M, Ashmarin I P, Mineeva M F, Anokhin K V
Biull Eksp Biol Med. 1981 Jul;92(7):31-3.
Under systemic administration tuftsin produces a marked influence on behavior and emotional reactivity in rats: enhances motor (vertical) activity, perception of pain stimulation and related aggressiveness and residual excitation. Activating effect is accompanied by an aggravation of the acquisition of passive avoidance reaction during single reinforcement. In vitro experiments revealed a direct inhibitory effect of tuftsin on the reaction rate of brain tyrosine hydroxylase activity. In vivo there was shown an increase in hypothalamic and especially striatal tyrosine hydroxylase activity. The data obtained indicate direct relationships between tuftsin central effects and the changes in brain catecholaminergic processes participating in the regulation of emotional-motivational and motor reactions.
在全身给药的情况下，促吞噬肽对大鼠的行为和情绪反应性产生显著影响：增强运动（垂直）活动、对疼痛刺激的感知以及相关的攻击性和残余兴奋。激活作用伴随着单次强化期间被动回避反应习得的加重。体外实验表明促吞噬肽对脑酪氨酸羟化酶活性的反应速率有直接抑制作用。在体内，下丘脑尤其是纹状体的酪氨酸羟化酶活性有所增加。所获得的数据表明促吞噬肽的中枢效应与参与调节情绪 - 动机和运动反应的脑儿茶酚胺能过程的变化之间存在直接关系。
