猫贝茨细胞的药理学研究。
Pharmacological studies on feline Betz cells.
作者信息
Crawford J M, Curtis D R
出版信息
J Physiol. 1966 Sep;186(1):121-38. doi: 10.1113/jphysiol.1966.sp008024.
Abstract
- A study has been made of the sensitivity of single neurones in the pericruciate cortex of anaesthetized and unanaesthetized cats to cholinomimetics administered electrophoretically from multibarrel micropipettes.2. A high proportion of deep pyramidal cells, including Betz cells, were excited by these substances, and the receptors involved have muscarinic characteristics.3. Atropine specifically reduced the sensitivity of cortical neurones to acetylcholine, but no such action could be demonstrated for dihydro-beta-erythroidine, gallamine or general anaesthetics.4. The significance of these results is discussed in relation to the possible synaptic or non-synaptic action of acetylcholine upon cortical neurones.
摘要
对麻醉和未麻醉猫的十字沟周围皮层单个神经元对通过多管微吸管电泳给予的拟胆碱药的敏感性进行了研究。
包括贝茨细胞在内的很大一部分深层锥体细胞被这些物质兴奋，且所涉及的受体具有毒蕈碱特性。
阿托品特异性降低皮层神经元对乙酰胆碱的敏感性，但二氢β-刺桐碱、加拉明或全身麻醉药未显示出这种作用。
结合乙酰胆碱对皮层神经元可能的突触或非突触作用对这些结果的意义进行了讨论。
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