Davies P, Josef J, Thompson A
Brain Res Bull. 1981 Oct;7(4):365-8. doi: 10.1016/0361-9230(81)90030-7.
Serial coronal sections were cut from frozen right cerebral hemispheres from five normal human brains. From each section samples of caudate nucleus, putamen, internal and external globus pallidus and substantia nigra were removed. Sampling was such that the entire structure was removed from each slice. The concentration of somatostatin-like immunoreactivity, expressed as units per mg protein, was found to vary between nuclei, and to vary along the anterior to posterior axis of some nuclei. Highest concentrations were found in the caudate nucleus, with the head and tail containing greater amounts than the body. The high concentrations in the head of the caudate may be due to contamination of samples of this region with adjacent nucleus accumbens. In a separate series of cases, the nucleus accumbens was shown to be considerably higher concentrations of somatostatin-like immunoreactivity than the head of the caudate. Concentrations in the putamen tended to decrease along the anterior to posterior axis. In the external globus pallidus, levels of somatostatin-like immunoreactivity showed the most striking changes along the anterior to posterior axis, rising 2.5 fold in the first three samples, and then falling 4 fold in the more posterior sections. The internal globus pallidus had generally lower concentrations, and these varied in a pattern opposite to that in the external globus pallidus. Levels in the substantia nigra were low compared to those in caudate and putamen.
从五个正常人类大脑的冷冻右大脑半球切取连续的冠状切片。从每个切片中取出尾状核、壳核、内苍白球、外苍白球和黑质的样本。取样方式为从每个切片中取出整个结构。以每毫克蛋白质的单位数表示的生长抑素样免疫反应性浓度在不同核之间有所变化，并且在一些核的前后轴上也有所变化。在尾状核中发现浓度最高，其头部和尾部的含量高于身体部分。尾状核头部的高浓度可能是由于该区域的样本被相邻的伏隔核污染。在另一系列病例中，伏隔核的生长抑素样免疫反应性浓度明显高于尾状核头部。壳核中的浓度倾向于沿前后轴降低。在外苍白球中，生长抑素样免疫反应性水平沿前后轴显示出最显著的变化，在前三个样本中上升2.5倍，然后在更靠后的切片中下降4倍。内苍白球的浓度通常较低，并且其变化模式与外苍白球相反。与尾状核和壳核相比，黑质中的水平较低。
