Hodge S E, Anderson C E, Neiswanger K, Field L L, Spence M A, Sparkes R S, Sparkes M C, Crist M, Terasaki P I, Rimoin D L, Rotter J I
Lancet. 1981 Oct 24;2(8252):893-5. doi: 10.1016/s0140-6736(81)91391-x.
27 polymorphic genetic markers were analysed for possible linkage with insulin-dependent diabetes mellitus (IDDM). The data set contained 71 families with at least one affected member each. Under three different genetic models for IDDM, evidence was found for linkage between the disease and two distinct sets of marker loci: three markers on chromosome 6 (HLA, properdin factor B, and glyoxalase-1), and the Kidd blood group locus. The families apparently do not fall into two groups, one exhibiting linkage to the HLA complex and the other to the Kidd locus. Thus, two distinct disease-susceptibility loci may be involved in the inheritance of IDDM.
对27个多态性基因标记进行了分析，以确定其与胰岛素依赖型糖尿病（IDDM）是否可能存在连锁关系。数据集包含71个家庭，每个家庭至少有一名患病成员。在三种不同的IDDM遗传模型下，发现该疾病与两组不同的标记基因座之间存在连锁关系：6号染色体上的三个标记（HLA、备解素因子B和乙二醛酶-1）以及基德血型基因座。这些家庭显然没有分成两组，一组显示与HLA复合体连锁，另一组与基德基因座连锁。因此，两个不同的疾病易感基因座可能参与了IDDM的遗传。
