Hodge S E, Anderson C E, Neiswanger K, Rubin R, Sparkes R S, Sparkes M C, Crist M, Spence M A, Terasaki P I, Rimoin D L
Diabetologia. 1983 Oct;25(4):343-7. doi: 10.1007/BF00253199.
One hundred and three unrelated patients with Type 1 (insulin-dependent) diabetes were typed for HLA, properdin factor B (BF), glyoxalase 1 (GLO), Kidd blood group, and 24 other genetic markers. Observed distributions of marker phenotypes among these patients were compared with those expected according to population frequencies, in an attempt to detect associations between Type 1 diabetes and the markers. Strong associations between Type 1 diabetes and both HLA and properdin factor B were confirmed, as was a lack of association between Type 1 diabetes and glyoxalase (GLO). There was an apparent deviation from Hardy-Weinberg equilibrium at the GLO locus, and statistically significant distortions in the distributions of pancreatic amylase (AMY2), galactose-1-phosphate uridyl transferase (GALT), and group-specific component (GC) among Type 1 diabetes patients, but these results are not significant when corrected for performance of multiple tests. An increase in the Lewis-negative phenotype reported elsewhere was observed here but was not statistically significant. A distortion in the distribution of Kidd types reported elsewhere was not confirmed.
对103例非亲属的1型（胰岛素依赖型）糖尿病患者进行了HLA、备解素因子B（BF）、乙二醛酶1（GLO）、基德血型以及其他24种遗传标记的分型。将这些患者中标记物表型的观察分布与根据群体频率预期的分布进行比较，以试图检测1型糖尿病与这些标记物之间的关联。1型糖尿病与HLA和备解素因子B之间的强关联得到证实，1型糖尿病与乙二醛酶（GLO）之间缺乏关联也得到证实。在GLO基因座处明显偏离哈迪-温伯格平衡，并且在1型糖尿病患者中胰腺淀粉酶（AMY2）、1-磷酸半乳糖尿苷转移酶（GALT）和组特异性成分（GC）的分布存在统计学上显著的畸变，但在对多次检验的表现进行校正后，这些结果并不显著。此处观察到了其他地方报道的Lewis阴性表型增加的情况，但无统计学意义。其他地方报道的基德血型分布畸变未得到证实。
