• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential responses to three neurohumoural agents.新皮质组织亚细胞成分中的环磷酸腺苷结合能力与组蛋白激酶激活。对三种神经体液因子的不同反应。
Biochem J. 1981 Feb 15;194(2):621-6. doi: 10.1042/bj1940621.
2
An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations.
FEBS Lett. 1985 May 20;184(2):339-42. doi: 10.1016/0014-5793(85)80634-7.
3
Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations. Effects of norepinephrine, histamine, carbamylcholine and 2-chloroadenosine.豚鼠大脑皮层制剂中肌醇磷酸酯和环磷酸腺苷的积累。去甲肾上腺素、组胺、氨基甲酰胆碱和2-氯腺苷的作用。
Biochim Biophys Acta. 1985 Nov 20;847(2):207-16. doi: 10.1016/0167-4889(85)90022-9.
4
Discriminatory effects of forskolin and EGTA on the indirect cyclic AMP responses to histamine, noradrenaline, 5-hydroxytryptamine, and glutamate in guinea-pig cerebral cortical slices.福斯高林和乙二醇双四乙酸对豚鼠大脑皮层切片中组胺、去甲肾上腺素、5-羟色胺和谷氨酸间接环磷酸腺苷反应的歧视性影响。
J Neurochem. 1990 May;54(5):1484-91. doi: 10.1111/j.1471-4159.1990.tb01195.x.
5
Persistence of increased histone kinase activity of neocortical tissues in relation to excitation and to adenosine 3':5'-cyclic monophosphate.新皮质组织中组蛋白激酶活性增加与兴奋及环磷酸腺苷的关系的持续性
Biochem Soc Trans. 1978;6(5):1006-8. doi: 10.1042/bst0061006.
6
Protein kinase activities in rat pancreatic islets of Langerhans.大鼠胰岛中的蛋白激酶活性
Biochem J. 1979 Apr 15;180(1):219-29. doi: 10.1042/bj1800219.
7
Cyclic AMP-generating systems in cell-free preparations from guinea pig cerebral cortex: loss of adenosine and amine responsiveness due to low levels of endogenous adenosine.豚鼠大脑皮层无细胞制剂中的环磷酸腺苷生成系统：内源性腺苷水平低导致对腺苷和胺反应性丧失
J Neurochem. 1980 Aug;35(2):338-42. doi: 10.1111/j.1471-4159.1980.tb06269.x.
8
Adenosine 3':5'-cyclic monophosphate-binding proteins in bovine and rat tissues.牛和大鼠组织中的3':5'-环磷酸腺苷结合蛋白
Biochem J. 1976 Nov;159(2):423-37. doi: 10.1042/bj1590423.
9
Cellular site and state combination of the adenosine 3':5'-cyclic monophosphate persisting after excitation of cerebral tissues.脑组织兴奋后持续存在的3':5'-环磷酸腺苷的细胞位点与状态组合。
Biochem J. 1978 Jan 15;170(1):73-9. doi: 10.1042/bj1700073.
10
Cyclic adenosine 3',5'-monophosphate in guinea-pig cerebral cortical slices: studies on the role of adenosine.
J Neurochem. 1975 Jun;24(6):1237-42. doi: 10.1111/j.1471-4159.1975.tb03904.x.

本文引用的文献

1
The binding of [3H]adenosine to synaptosomal and other preparations from the mammalian brain.[3H]腺苷与哺乳动物脑突触体及其他制剂的结合。
Biochem J. 1981 Feb 15;194(2):611-20. doi: 10.1042/bj1940611.
2
Adenosine-binding to cerebral preparations in interpretation of adenosine activation of adenosine 3':5'-cyclic monophosphate formation [proceedings].
Biochem Soc Trans. 1980 Feb;8(1):141-2. doi: 10.1042/bst0080141.
3
Stimulation of piriform- and neo-cortical tissues in an in vitro flow-system: metabolic properties and release of putative neurotransmitters.体外流动系统中梨状皮质和新皮质组织的刺激：代谢特性及假定神经递质的释放
J Neurochem. 1970 Apr;17(4):521-30. doi: 10.1111/j.1471-4159.1970.tb00530.x.
4
Depolarization-evoked accumulation of cyclic AMP in brain slices: inhibition by exogenous adenosine deaminase.去极化诱发脑片中环磷酸腺苷的积累：外源性腺苷脱氨酶的抑制作用。
Biochim Biophys Acta. 1973 Nov 2;329(1):147-51. doi: 10.1016/0304-4165(73)90017-2.
5
Intracellular titration of cyclic AMP bound to receptor proteins and correlation with cyclic-AMP levels in the surviving rat diaphragm.与受体蛋白结合的环磷酸腺苷的细胞内滴定及其与存活大鼠膈肌中环磷酸腺苷水平的相关性
Eur J Biochem. 1973 Dec 3;40(1):177-85. doi: 10.1111/j.1432-1033.1973.tb03183.x.
6
The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.腺苷及腺嘌呤核苷酸对豚鼠大脑皮层切片中3',5'-环磷酸腺苷含量的影响。
Mol Pharmacol. 1970 Jan;6(1):13-23.
7
Protein kinase activity in membrane preparations from ox brain. Stimulation of intrinsic activity by adenosine 3':5'-cyclic monophosphate.牛脑细胞膜制剂中的蛋白激酶活性。3':5'-环磷酸腺苷对内在活性的刺激作用。
Biochem J. 1973 Mar;132(3):483-92. doi: 10.1042/bj1320483.
8
Turnover of protein-bound serine phosphate in respiring slices of guinea-pig cerebral cortex. Effects of putative transmitters, tetrodotoxin and other agents.豚鼠大脑皮层呼吸切片中蛋白质结合丝氨酸磷酸的周转。假定递质、河豚毒素及其他试剂的作用。
Biochem J. 1973 Mar;132(3):475-82. doi: 10.1042/bj1320475.
9
Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts.3',5'-环磷酸腺苷依赖性蛋白激酶的调节。I. 粗提物中脂肪组织酶的初步特性
J Biol Chem. 1973 Mar 10;248(5):1813-21.
10
Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases.克雷布斯·E·G：3',5'-环磷酸腺苷依赖性蛋白激酶的一种蛋白抑制剂的纯化与特性鉴定
J Biol Chem. 1971 Apr 10;246(7):1977-85.

新皮质组织亚细胞成分中的环磷酸腺苷结合能力与组蛋白激酶激活。对三种神经体液因子的不同反应。

Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential responses to three neurohumoural agents.

作者信息

Patel J, Newman M, McIlwain H

出版信息

Biochem J. 1981 Feb 15;194(2):621-6. doi: 10.1042/bj1940621.

DOI:10.1042/bj1940621
PMID:6118136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162787/
Abstract
  1. Noradrenaline and histamine, when added to superfused guinea-pig cerebral-cortical tissues, increased both cyclic AMP-dependent and -independent histone kinase activities of some, but not of all, subsequently isolated subcellular fractions, and decreased their cyclic [(3)H]AMP-binding capacity, which was concluded to be due to an increase in endogenously bound cyclic AMP. 2. Adenosine and 2-chloroadenosine also diminished the cyclic [(3)H]AMP-binding capacities, but did not affect the histone kinase activities. 3. DEAE-cellulose chromatography and stability to KCl additions showed that the greater part of the histone kinase of the present preparations corresponded to the type II enzyme [of Corbin, Keely & Park (1975) J. Biol. Chem.250, 218-225], with a lesser amount of type I activity. Different sites of cyclic AMP accumulation in relation to these or other kinases are considered in interpreting the differential tissue responses to the neurohumoural agents examined.
摘要
  1. 去甲肾上腺素和组胺添加到灌流的豚鼠大脑皮质组织中时，会增加部分（而非全部）随后分离出的亚细胞组分中依赖环磷酸腺苷（cAMP）和不依赖cAMP的组蛋白激酶活性，并降低其环[³H]AMP结合能力，得出这是由于内源性结合的环磷酸腺苷增加所致。2. 腺苷和2 - 氯腺苷也会降低环[³H]AMP结合能力，但不影响组蛋白激酶活性。3. 二乙氨基乙基纤维素色谱分析以及对添加氯化钾的稳定性表明，本制剂中大部分组蛋白激酶对应于[科尔宾、基利和帕克（1975年）《生物化学杂志》250, 218 - 225]的II型酶，I型活性较少。在解释对所研究的神经体液因子的不同组织反应时，考虑了与这些或其他激酶相关的环磷酸腺苷积累的不同位点。