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脑组织兴奋后持续存在的3':5'-环磷酸腺苷的细胞位点与状态组合。

Cellular site and state combination of the adenosine 3':5'-cyclic monophosphate persisting after excitation of cerebral tissues.

作者信息

Newman M, McIlwain H

出版信息

Biochem J. 1978 Jan 15;170(1):73-9. doi: 10.1042/bj1700073.

DOI:10.1042/bj1700073
PMID:204301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1183862/
Abstract
  1. The subcellular distribution of cyclic AMP in guinea-pig cerebral-cortical tissue was determined before and after electrical stimulation, and after a period of continued incubation after electrical stimulation, with and without the presence of histamine. 2. Electrical stimulation and histamine increased the cyclic AMP content of all fractions, the greatest increase occurring in the supernatant fraction. 3. Continued incubation after cessation of electrical stimulation diminished the cyclic AMP of the total homogenate and supernatant fractions, but increased that of the synaptosomal fraction. 4. Further fractionation of the synaptosomal fractions from stimulated tissues suggested that most of their soluble cyclic AMP was in a higher-molecular-weight form than was that of the tissue supernatant. 5. It is suggested that protein binding and cytoplasmic transport of cyclic AMP are involved in the changes observed.
摘要
  1. 在有组胺和无组胺存在的情况下，分别测定了电刺激前后以及电刺激后持续孵育一段时间后豚鼠大脑皮质组织中环磷酸腺苷（cAMP）的亚细胞分布。2. 电刺激和组胺均增加了所有组分中的cAMP含量，其中上清液组分增加最为显著。3. 电刺激停止后持续孵育，总匀浆和上清液组分中的cAMP含量减少，但突触体组分中的cAMP含量增加。4. 对受刺激组织的突触体组分进一步分级分离表明，其大部分可溶性cAMP的分子量高于组织上清液中的cAMP。5. 提示所观察到的变化涉及cAMP的蛋白质结合和细胞质转运。

相似文献

1
Cellular site and state combination of the adenosine 3':5'-cyclic monophosphate persisting after excitation of cerebral tissues.脑组织兴奋后持续存在的3':5'-环磷酸腺苷的细胞位点与状态组合。
Biochem J. 1978 Jan 15;170(1):73-9. doi: 10.1042/bj1700073.
2
Change of cycle AMP level in synaptosomes from cerebral cortex; increase by adenosine derivatives.大脑皮质突触体中环磷酸腺苷水平的变化；腺苷衍生物使其升高。
J Neurochem. 1981 Jan;36(1):86-91. doi: 10.1111/j.1471-4159.1981.tb02381.x.
3
Adenosine 3':5'-cyclic monophosphate in nerve-terminal fractions from neocortical tissues: its augmentation by a post-stimulation process [proceedings].来自新皮质组织神经末梢部分的3':5'-环磷酸腺苷：其通过刺激后过程的增加[会议论文]
Biochem Soc Trans. 1977;5(4):1074-5. doi: 10.1042/bst0051074.
4
Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential responses to three neurohumoural agents.新皮质组织亚细胞成分中的环磷酸腺苷结合能力与组蛋白激酶激活。对三种神经体液因子的不同反应。
Biochem J. 1981 Feb 15;194(2):621-6. doi: 10.1042/bj1940621.
5
Turnover of protein-bound serine phosphate in respiring slices of guinea-pig cerebral cortex. Effects of putative transmitters, tetrodotoxin and other agents.豚鼠大脑皮层呼吸切片中蛋白质结合丝氨酸磷酸的周转。假定递质、河豚毒素及其他试剂的作用。
Biochem J. 1973 Mar;132(3):475-82. doi: 10.1042/bj1320475.
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Cyclic AMP-generating systems in cell-free preparations from guinea pig cerebral cortex: loss of adenosine and amine responsiveness due to low levels of endogenous adenosine.豚鼠大脑皮层无细胞制剂中的环磷酸腺苷生成系统：内源性腺苷水平低导致对腺苷和胺反应性丧失
J Neurochem. 1980 Aug;35(2):338-42. doi: 10.1111/j.1471-4159.1980.tb06269.x.
7
The stimulatory effect of the boiled supernatant on cyclic AMP formation in synaptosomes from rat cerebral cortex.煮沸上清液对大鼠大脑皮质突触体中环磷酸腺苷形成的刺激作用。
Jpn J Pharmacol. 1975 Aug;25(4):375-81. doi: 10.1254/jjp.25.375.
8
Temporal changes in the calcium-dependence of the histamine H1-receptor-stimulation of cyclic AMP accumulation in guinea-pig cerebral cortex.豚鼠大脑皮层中组胺H1受体刺激环磷酸腺苷积累的钙依赖性的时间变化。
Br J Pharmacol. 1989 Dec;98(4):1365-75. doi: 10.1111/j.1476-5381.1989.tb12686.x.
9
Stimulation of adenosine 3',5'-monophosphate formation in guinea-pig cerebral cortical slices in a calcium free medium.在无钙培养基中对豚鼠大脑皮质切片中3',5'-环磷酸腺苷形成的刺激作用
Naunyn Schmiedebergs Arch Pharmacol. 1975;287(3):289-96. doi: 10.1007/BF00501474.
10
Adenosine as a constituent of the brain and of isolated cerebral tissues, and its relationship to the generation of adenosine 3':5'-cyclic monophosphate.腺苷作为大脑及离体脑组织的一种成分，及其与3':5'-环磷酸腺苷生成的关系。
Biochem J. 1977 Apr 15;164(1):131-7. doi: 10.1042/bj1640131.

引用本文的文献

1
The binding of [3H]adenosine to synaptosomal and other preparations from the mammalian brain.[3H]腺苷与哺乳动物脑突触体及其他制剂的结合。
Biochem J. 1981 Feb 15;194(2):611-20. doi: 10.1042/bj1940611.
2
Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential responses to three neurohumoural agents.新皮质组织亚细胞成分中的环磷酸腺苷结合能力与组蛋白激酶激活。对三种神经体液因子的不同反应。
Biochem J. 1981 Feb 15;194(2):621-6. doi: 10.1042/bj1940621.

本文引用的文献

1
Nucleotide metabolism in rat brain.大鼠脑内的核苷酸代谢
J Neurochem. 1968 May;15(5):367-76. doi: 10.1111/j.1471-4159.1968.tb11623.x.
2
The effect of electrical stimulation upon the accumulation of adenosine 3',5'-phosphate in isolated cerebral tissue.电刺激对离体脑组织中3',5'-磷酸腺苷积累的影响。
J Neurochem. 1969 Apr;16(4):485-91. doi: 10.1111/j.1471-4159.1969.tb06847.x.
3
Absence of an effect of histamine, noradrenaline and depolarizing agents on the levels of adenosine 3', 5'-monophosphate in nerve endings isolated from cerebral cortex.组胺、去甲肾上腺素及去极化剂对从大脑皮层分离出的神经末梢中3',5'-环磷酸腺苷水平无影响。
Biochem Pharmacol. 1974 Feb 15;23(4):835-43. doi: 10.1016/0006-2952(74)90214-7.
4
Output of (14C)adenine nucleotides and their derivatives from cerebral tissues. Tetrodotoxin-resistant and calcium ion-requiring components.(14C)腺嘌呤核苷酸及其衍生物从脑组织中的输出。河豚毒素抗性和钙离子需求成分。
Biochem J. 1973 Dec;136(4):893-901. doi: 10.1042/bj1360893.
5
Subcellular localization of (14C)adenine derivatives newly-formed in cerebral tissues and the effects of electrical excitation.脑组织中新形成的（14C）腺嘌呤衍生物的亚细胞定位及电刺激的影响。
J Neurochem. 1973 Oct;21(4):889-900. doi: 10.1111/j.1471-4159.1973.tb07534.x.
6
Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline.二丁酰环磷腺苷和茶碱促使交感神经增强释放多巴胺-β-羟化酶和去甲肾上腺素。
Mol Pharmacol. 1973 Mar;9(2):178-83.
7
Noradrenergic stimulation of cyclic adenosine monophosphate in rat Purkinje neurons: an immunocytochemical study.去甲肾上腺素能对大鼠浦肯野神经元中环磷酸腺苷的刺激作用：一项免疫细胞化学研究。
Science. 1973 Feb 9;179(4073):585-8. doi: 10.1126/science.179.4073.585.
8
Cyclic adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices. I. Formation of cyclic adenosine 3',5'-monophosphate from endogenous adenosine triphosphate and from radioactive adenosine triphosphate formed during a prior incubation with radioactive adenine.豚鼠大脑皮质切片中的环磷酸腺苷3',5'-单磷酸。I. 由内源性三磷酸腺苷以及在先前与放射性腺嘌呤孵育期间形成的放射性三磷酸腺苷形成环磷酸腺苷3',5'-单磷酸。
J Biol Chem. 1973 Feb 10;248(3):843-52.
9
Effect of probenecid on levels of cyclic AMP in human cerebrospinal fluid.丙磺舒对人脑脊液中环磷酸腺苷水平的影响。
J Neurochem. 1972 Jun;19(6):1601-2. doi: 10.1111/j.1471-4159.1972.tb05104.x.
10
Subcellular fractionation of cultured glial cells.培养的神经胶质细胞的亚细胞分级分离
J Neurobiol. 1971;2(2):169-80. doi: 10.1002/neu.480020209.