脑组织兴奋后持续存在的3':5'-环磷酸腺苷的细胞位点与状态组合。
Cellular site and state combination of the adenosine 3':5'-cyclic monophosphate persisting after excitation of cerebral tissues.
作者信息
Newman M, McIlwain H
出版信息
Biochem J. 1978 Jan 15;170(1):73-9. doi: 10.1042/bj1700073.
Abstract
- The subcellular distribution of cyclic AMP in guinea-pig cerebral-cortical tissue was determined before and after electrical stimulation, and after a period of continued incubation after electrical stimulation, with and without the presence of histamine. 2. Electrical stimulation and histamine increased the cyclic AMP content of all fractions, the greatest increase occurring in the supernatant fraction. 3. Continued incubation after cessation of electrical stimulation diminished the cyclic AMP of the total homogenate and supernatant fractions, but increased that of the synaptosomal fraction. 4. Further fractionation of the synaptosomal fractions from stimulated tissues suggested that most of their soluble cyclic AMP was in a higher-molecular-weight form than was that of the tissue supernatant. 5. It is suggested that protein binding and cytoplasmic transport of cyclic AMP are involved in the changes observed.
摘要
- 在有组胺和无组胺存在的情况下，分别测定了电刺激前后以及电刺激后持续孵育一段时间后豚鼠大脑皮质组织中环磷酸腺苷（cAMP）的亚细胞分布。2. 电刺激和组胺均增加了所有组分中的cAMP含量，其中上清液组分增加最为显著。3. 电刺激停止后持续孵育，总匀浆和上清液组分中的cAMP含量减少，但突触体组分中的cAMP含量增加。4. 对受刺激组织的突触体组分进一步分级分离表明，其大部分可溶性cAMP的分子量高于组织上清液中的cAMP。5. 提示所观察到的变化涉及cAMP的蛋白质结合和细胞质转运。
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Biochem J. 1981 Feb 15;194(2):621-6. doi: 10.1042/bj1940621.
本文引用的文献
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Nucleotide metabolism in rat brain.大鼠脑内的核苷酸代谢
J Neurochem. 1968 May;15(5):367-76. doi: 10.1111/j.1471-4159.1968.tb11623.x.
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The effect of electrical stimulation upon the accumulation of adenosine 3',5'-phosphate in isolated cerebral tissue.电刺激对离体脑组织中3',5'-磷酸腺苷积累的影响。
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Absence of an effect of histamine, noradrenaline and depolarizing agents on the levels of adenosine 3', 5'-monophosphate in nerve endings isolated from cerebral cortex.组胺、去甲肾上腺素及去极化剂对从大脑皮层分离出的神经末梢中3',5'-环磷酸腺苷水平无影响。
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Output of (14C)adenine nucleotides and their derivatives from cerebral tissues. Tetrodotoxin-resistant and calcium ion-requiring components.(14C)腺嘌呤核苷酸及其衍生物从脑组织中的输出。河豚毒素抗性和钙离子需求成分。
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Subcellular localization of (14C)adenine derivatives newly-formed in cerebral tissues and the effects of electrical excitation.脑组织中新形成的（14C）腺嘌呤衍生物的亚细胞定位及电刺激的影响。
J Neurochem. 1973 Oct;21(4):889-900. doi: 10.1111/j.1471-4159.1973.tb07534.x.
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Noradrenergic stimulation of cyclic adenosine monophosphate in rat Purkinje neurons: an immunocytochemical study.去甲肾上腺素能对大鼠浦肯野神经元中环磷酸腺苷的刺激作用：一项免疫细胞化学研究。
Science. 1973 Feb 9;179(4073):585-8. doi: 10.1126/science.179.4073.585.
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