Gottrup F
Scand J Gastroenterol. 1981;16(2):213-8. doi: 10.3109/00365528109181958.
The effect of a selective beta2-adrenoceptor agonist on urecholine-stimulated gastric acid secretion was studied in conscious gastric fistula dogs. A dose-dependent inhibition was found, most pronounced for the highest doses of urecholine. The inhibition was primarily on volume, whereas the acidity showed a decreasing tendency only. The pulse rate was increased by the beta2-agonist and by urecholine in high doses. Propranolol prevented both the inhibition of acid secretion and the increase in pulse rate. Practolol had no effect on the inhibition of acid secretion and the increase in pulse rate. Practolol had no effect on the inhibition of acid secretion but prevented the increase in pulse rate. Dose-response experiments with five doses of urecholine and two doses of the beta2-agonist showed a decrease in maximal response, and transformation of the curve suggested an unchanged D50. It is concluded that the beta2-agonist inhibits urecholine-stimulated acid secretion in the dog to the same degree as pentagastrin-induced acid secretion, and much stronger than found for histamine-induced acid secretion in earlier experiments. The inhibition seems to follow a noncompetitive kinetic, and beta2-receptors are probable involved.
在清醒的胃瘘犬中研究了选择性β2 -肾上腺素能受体激动剂对乌拉胆碱刺激胃酸分泌的影响。发现存在剂量依赖性抑制，对最高剂量的乌拉胆碱最为明显。抑制主要作用于分泌量，而酸度仅呈下降趋势。β2 -激动剂和高剂量的乌拉胆碱均可使心率增加。普萘洛尔可同时防止胃酸分泌的抑制和心率增加。醋丁洛尔对胃酸分泌的抑制和心率增加均无影响。醋丁洛尔对胃酸分泌的抑制无作用，但可防止心率增加。用五剂乌拉胆碱和两剂β2 -激动剂进行的剂量反应实验显示最大反应降低，曲线转变表明半数有效剂量（D50）不变。结论是，β2 -激动剂对犬乌拉胆碱刺激的胃酸分泌的抑制程度与五肽胃泌素诱导的胃酸分泌相同，且比早期实验中组胺诱导的胃酸分泌的抑制作用强得多。这种抑制似乎遵循非竞争性动力学，可能涉及β2 -受体。
