Gottrup F, Ornsholt J
Scand J Gastroenterol. 1979;14(3):321-6. doi: 10.3109/00365527909179890.
The effect of a selective beta2-adrenoceptor agonist on histamine-stimulated gastric acid secretion was studied in conscious gastric-fistula dogs. A dose-dependent inhibition was found, most pronounced for the lowest doses of histamine. The inhibition was on the volume, whereas the acidity was unchanged. The pulse rate was increased by the beta2-agonist and by histamine. Propranolol prevented the inhibition of acid secretion as well as the increase in pulse rate. Practolol had no effect on the inhibition of acid secretion but reduced the increase in pulse rate. Dose-response experiments with six doses of histamine and two doses of the beta2-agonist showed unchanged calculated maximal response and an increase in D50. It is concluded that the beta2-agonist inhibits histamine-induced acid secretion in the dog, but to a lesser degree that pentagastrin-induced acid secretion, as found in earlier experiments. The inhibition follows competitive kinetics, and beta2-receptors are probably involved. The influence of beta2-sympathomimetics on the mechanism of gastric acid secretion is discussed.
在清醒的胃瘘犬中研究了选择性β2-肾上腺素能受体激动剂对组胺刺激胃酸分泌的影响。发现存在剂量依赖性抑制，对最低剂量的组胺最为明显。抑制作用在于分泌量，而酸度未变。β2-激动剂和组胺均可使心率增加。普萘洛尔可防止胃酸分泌的抑制以及心率的增加。醋丁洛尔对胃酸分泌的抑制无作用，但可减轻心率的增加。用六种剂量的组胺和两种剂量的β2-激动剂进行的剂量反应实验表明，计算得出的最大反应不变，而半数有效量（D50）增加。得出的结论是，β2-激动剂可抑制犬组胺诱导的胃酸分泌，但程度低于早期实验中发现的五肽胃泌素诱导的胃酸分泌。这种抑制遵循竞争性动力学，可能涉及β2-受体。讨论了β2-拟交感神经药对胃酸分泌机制的影响。
