Tobi M, Morag A, Ravid Z, Chowers I, Feldman-Weiss V, Michaeli Y, Ben-Chetrit E, Shalit M, Knobler H
Lancet. 1982 Jan 9;1(8263):61-4. doi: 10.1016/s0140-6736(82)90210-0.
Seven patients with prolonged atypical illness were followed up for more than a year. Sera taken during that period showed significantly increased titres of IgM antibodies against the viral capsid antigen (VCA) of Epstein-Barr virus (EBV). In four of the patients antibodies to the R component of the early antigen (EA) complex of EBV were clearly detectable. Only one of these seven patients had presented with symptoms of classic infectious mononucleosis. Serological and clinical observations in these patients suggest that the prolonged atypical illness was probably the result of persistent EBV infection.
对7例患有持续性非典型疾病的患者进行了为期一年多的随访。在此期间采集的血清显示，针对EB病毒（EBV）病毒衣壳抗原（VCA）的IgM抗体滴度显著升高。在4例患者中可明显检测到针对EBV早期抗原（EA）复合物R成分的抗体。这7例患者中只有1例出现了典型传染性单核细胞增多症的症状。对这些患者的血清学和临床观察表明，这种持续性非典型疾病可能是EBV持续感染的结果。
