Weingart J, Kunert H, Ottenjann R
Scand J Gastroenterol Suppl. 1981 Jun;69:61-5.
It is known that intravenous amino acid infusions stimulate gastric acid secretion. In 20 healthy volunteers we studied the effect of amino acid infusion on gastric acid secretion and inhibition of the latter by the H2-receptor antagonists ranitidine and cimetidine. Acid output was measured by modified intragastric titration. Initial stimulation of acid secretion until plateau levels was achieved by pentagastrin infusion 2 micrograms kg-1 h-1. After 30 min a standard amino acid infusion at 2.1 ml kg-1 h-1 was started, together with a bolus injection of either cimetidine 200 mg in group 1 (n = 10), or ranitidine 50 mg in group 2 (n = 10). Normal saline served as a control in both groups on a second occasion. The amino acid infusion was continued for 60 min and gastric acid output redetermined until constant. Amino acid infusion increased gastric acid secretion by 67% above submaximal pentagastrin-stimulated level in group 1 and by 47% in group 2. With concurrent administration of an H2-receptor antagonist in the presence of amino acid infusion, gastric acid secretion was inhibited by 41.4% (P less than 0.004) by cimetidine and by 52.9% (P less than 0.001) by ranitidine below initial pentagastrin-stimulated levels. In order to avoid the increased acid output produced by amino acid infusions, it therefore may be desirable to administer an H2-receptor antagonist concurrently.
已知静脉输注氨基酸会刺激胃酸分泌。我们在20名健康志愿者中研究了氨基酸输注对胃酸分泌的影响以及H2受体拮抗剂雷尼替丁和西咪替丁对胃酸分泌的抑制作用。采用改良的胃内滴定法测量酸排出量。通过以2微克/千克·小时的速度输注五肽胃泌素，初始刺激胃酸分泌直至达到平台期水平。30分钟后，开始以2.1毫升/千克·小时的速度进行标准氨基酸输注，同时在第1组（n = 10）中静脉注射200毫克西咪替丁，或在第2组（n = 10）中静脉注射50毫克雷尼替丁。两组在另一次实验中均以生理盐水作为对照。氨基酸输注持续60分钟，重新测定胃酸排出量直至稳定。氨基酸输注使第1组胃酸分泌量比次最大五肽胃泌素刺激水平高出67%，第2组高出47%。在输注氨基酸的同时给予H2受体拮抗剂，西咪替丁使胃酸分泌量比初始五肽胃泌素刺激水平降低41.4%（P < 0.004），雷尼替丁降低52.9%（P < 0.001）。因此，为避免氨基酸输注引起的胃酸排出量增加，同时给予H2受体拮抗剂可能是可取的。
