Dammann H G, Simon B
Scand J Gastroenterol Suppl. 1981 Jun;69:39-43.
The antisecretory effects of a new histamine H2-receptor antagonist ranitidine hydrochloride 150 mg, have been tested on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration. In addition, the 24 h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three oral doses of ranitidine 150 mg per day. A significant inhibition of basal acid output has been observed up to 10 h after the drug. The intragastric pH remained above 5 for at least 24 h. Ranitidine has proven to be a more potent and longer acting antisecretory compound than cimetidine.
对健康志愿者口服150毫克新型组胺H2受体拮抗剂盐酸雷尼替丁后5小时和10小时，检测了其对基础胃酸分泌和五肽胃泌素刺激胃酸分泌的抑制作用。此外，对接受肠外营养的患者，每天口服三次150毫克雷尼替丁后，测量了其24小时胃内pH值变化曲线。用药后长达10小时观察到基础胃酸分泌受到显著抑制。胃内pH值至少24小时保持在5以上。事实证明，雷尼替丁是一种比西咪替丁更有效、作用时间更长的抗分泌化合物。
