Rifat K, Morel D, Gamulin Z, Szappanyos G
Ann Anesthesiol Fr. 1981;22(4):322-8.
A group of elderly (mean age: 75 years) patients undergoing a prothetic on the hip under analgesic anaesthesia using fentanyl by continuous infusion (7 micrograms.kg.h(-1)) was compared with a similar group receiving sequential analgesic anaesthesia using fentanyl (25 micrograms.kg as a bolus then 7 micrograms.kg(-1).2030mins(-1)). Comparison of the results obtained revealed a variation in mean cardiocirculatory parameters which was less marked in the group receiving fentanyl by infusion than in the group receiving it sequentially. The higher doses used in the sequential analgesia group led in the majority of cases to severe respiratory depression requiring its reversal by an antagonist or postoperative ventilatory assistance, whilst the use of fentanyl by infusion made it possible to reduce total doses of the drug and ensure adequate spontaneous respiration at the end of the operation.
一组老年患者（平均年龄：75岁）在镇痛麻醉下接受髋关节假体植入手术，通过持续输注芬太尼（7微克·千克·小时⁻¹），并与另一组接受序贯镇痛麻醉使用芬太尼（25微克·千克作为负荷剂量，然后7微克·千克⁻¹·20 - 30分钟⁻¹）的类似患者组进行比较。对所得结果的比较显示，平均心血管循环参数存在差异，输注芬太尼组的差异比序贯给药组的差异不那么明显。序贯镇痛组使用的较高剂量在大多数情况下导致严重呼吸抑制，需要用拮抗剂逆转或术后通气辅助，而输注芬太尼则可以减少药物总剂量，并确保手术结束时自主呼吸充分。
