柳氮磺胺吡啶可抑制中性粒细胞趋化脂质的合成。
Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.
作者信息
Stenson W F, Lobos E
出版信息
J Clin Invest. 1982 Feb;69(2):494-7. doi: 10.1172/jci110474.
Abstract
Neutrophils metabolize arachidonic acid through the liposygenase pathway to 5-hydroxy-6,8,11,14-eicosatetrenoic acid (5-HETE) and 5,12-dihydroxy-6,8,10,14-eicosatraenoic acid (5,12 diHETE). 5-HETE and 5,12diHETE are potent chemotactic agents and are thought to have important roles in the inflammatory response. In this study we demonstrate the sulfasalazine, at concentrations found in the stool of patients being treated for ulcerative colitis, blocks the synthesis of both 5-HETE and 5,12 diHETE by human neutrophils. A sulfasalazine metabolite, 5-aminosalicylate, also blocks the synthesis of 5,12 diHETE.
摘要
中性粒细胞通过脂氧合酶途径将花生四烯酸代谢为5-羟基-6,8,11,14-二十碳四烯酸（5-HETE）和5,12-二羟基-6,8,10,14-二十碳四烯酸（5,12-二HETE）。5-HETE和5,12-二HETE是强效趋化剂，被认为在炎症反应中起重要作用。在本研究中，我们证明，柳氮磺胺吡啶在溃疡性结肠炎患者粪便中发现的浓度下，可阻断人中性粒细胞合成5-HETE和5,12-二HETE。柳氮磺胺吡啶的一种代谢产物5-氨基水杨酸也可阻断5,12-二HETE的合成。
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本文引用的文献
1
2
Monohydroxyeicosatetraenoic acids (HETEs) induce degranulation of human neutrophils.单羟基二十碳四烯酸（HETEs）可诱导人中性粒细胞脱颗粒。
J Immunol. 1980 May;124(5):2100-4.
3
Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.通过脂氧合酶和对抗炎药敏感的12L-氢过氧-5,8,10,14-二十碳四烯酸过氧化物酶进行的花生四烯酸代谢。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):308-12. doi: 10.1073/pnas.77.1.308.
4
Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates.
Biochem Biophys Res Commun. 1980 Jan 29;92(2):688-95. doi: 10.1016/0006-291x(80)90388-5.
5
Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B.白三烯B对人中性粒细胞趋化活性的新型结构决定因素
J Exp Med. 1981 Feb 1;153(2):482-7. doi: 10.1084/jem.153.2.482.
6
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Nature. 1980 Jul 17;286(5770):264-5. doi: 10.1038/286264a0.
7
Studies of prostaglandins and sulphasalazine in ulcerative colitis.溃疡性结肠炎中前列腺素与柳氮磺胺吡啶的研究。
Prostaglandins Med. 1981 Feb;6(2):165-82. doi: 10.1016/0161-4630(81)90088-4.
8
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9
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10
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J Exp Med. 1979 Aug 1;150(2):406-11. doi: 10.1084/jem.150.2.406.
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