人中性粒细胞从花生四烯酸生成独特的单羟基二十碳四烯酸
Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.
作者信息
Goetzl E J, Sun F F
出版信息
J Exp Med. 1979 Aug 1;150(2):406-11. doi: 10.1084/jem.150.2.406.
Abstract
Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE greater than 8-HETE = 9-HETE greater than 11-HETE = 12-HETE. The expression of chemokinetic activity as well as chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils.
摘要
在吲哚美辛存在的情况下，将[3H]花生四烯酸与人中性粒细胞匀浆的17,000 - g上清液一起温育，除了生成12 - HETE、11 - HETE和5 - HETE外，还产生了独特的代谢产物9 - OH - 5,7,11,14 - 二十碳四烯酸（9 - HETE）和8 - HETE。HETE产物的人中性粒细胞趋化活性呈现出效力等级顺序为5 - HETE大于8 - HETE = 9 - HETE大于11 - HETE = 12 - HETE。化学动力学活性以及趋化活性的表达表明，这些物质的内源性产生可能会影响人中性粒细胞的迁移能力。
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