Hilsted J, Madsbad S, Krarup T, Tronier B, Galbo H, Sestoft L, Schwartz T W
J Clin Endocrinol Metab. 1982 Apr;54(4):815-9. doi: 10.1210/jcem-54-4-815.
The responses of pancreatic hormones (i.e. glucagon, pancreatic polypeptide, and somatostatin) to insulin-induced hypoglycemia were investigated in 18 insulin-dependent diabetics without residual beta-cell function and in 6 normal subjects. Nine of the diabetics had autonomic neuropathy, and 9 had no neuropathy. After hypoglycemia, no significant increase in any of the 3 pancreatic hormones was found in the diabetics with autonomic neuropathy, whereas significant increments were found in the diabetics without neuropathy and in the normal subjects. These results suggest that autonomic nervous activity is of major importance for pancreatic hormone release during hypoglycemia in man.
在18例无残余β细胞功能的胰岛素依赖型糖尿病患者及6名正常受试者中，研究了胰高血糖素、胰多肽和生长抑素这几种胰腺激素对胰岛素诱发低血糖的反应。其中9例糖尿病患者有自主神经病变，9例无神经病变。低血糖发生后，有自主神经病变的糖尿病患者的这3种胰腺激素均未出现显著升高，而无神经病变的糖尿病患者及正常受试者则出现了显著升高。这些结果表明，自主神经活动对人类低血糖期间胰腺激素的释放至关重要。
