Hilsted J, Madsbad S, Krarup T, Heding L G, Sestoft L
Acta Med Scand Suppl. 1980;639:25-8. doi: 10.1111/j.0954-6820.1980.tb12860.x.
Glucagon and metabolic responses to insulin-induced hypoglycemia were studied in seven juvenile diabetics, age 31 +/- 2 years (mean and S.E.M.), duration of diabetes 17 +/- 3 years, with diabetic autonomic neuropathy (decreased beat-to-beat variation in heart rate during hyperventilation and/or orthostatic hypotension) and in seven control patients of similar age and duration of diabetes with out neuropathy. Before the hypoglycaemic episode, normoglycemia had been maintained for at least 10 hours. Following hypoglycemia, a slight but significant and similar increase in plasma glucagon was found in both patient groups. Metabolic responses to hypoglycemia were also similar in the two patient groups. In conclusion, diabetic autonomic neuropathy has no effect on glucagon and metabolic responses to hypoglycemia in juvenile, insulin-treated diabetics.
对7名青少年糖尿病患者（年龄31±2岁，平均及标准误；糖尿病病程17±3年）及7名年龄和糖尿病病程相似但无神经病变的对照患者进行了胰高血糖素及对胰岛素诱导的低血糖的代谢反应研究。这些糖尿病患者患有糖尿病自主神经病变（过度通气期间心率逐搏变化降低和/或体位性低血压）。在低血糖发作前，正常血糖已维持至少10小时。低血糖发生后，两组患者血浆胰高血糖素均有轻微但显著且相似的升高。两组患者对低血糖的代谢反应也相似。总之，糖尿病自主神经病变对青少年胰岛素治疗的糖尿病患者的胰高血糖素及对低血糖的代谢反应无影响。
