Mest H J, Winkler J, Förster W
Acta Biol Med Ger. 1977;36(7-8):1193-6.
The antiarrhythmic effect of PGE2 as compared with the adrenergic beta-receptor blocking substance propranolol and the unspecific antiarrhythmic agent ajmaline was examanined on catecholamine-induced arrhythmias of the guinea-pig after preliminary sensibilisation by means of chloroform. Prophylactic administration of the tested substances resulted in a decrease in severity of arrhythmia by 91% after propranolol, by 37% after PGE2 and by 34% after ajmaline. Onset and duration of the arrhythmia were affected only to a negligible degree. The possible mode of action is still under discussion.
在通过氯仿进行初步致敏后，研究了前列腺素E2（PGE2）与肾上腺素能β受体阻滞剂普萘洛尔以及非特异性抗心律失常药阿马林相比，对豚鼠儿茶酚胺诱导的心律失常的抗心律失常作用。预防性给予受试物质后，普萘洛尔使心律失常严重程度降低91%，PGE2使心律失常严重程度降低37%，阿马林使心律失常严重程度降低34%。心律失常的发作和持续时间仅受到微不足道的影响。其可能的作用方式仍在讨论中。
