Mest H J, Blass K E, Förster W
Acta Biol Med Ger. 1976;35(1):63-7.
The prostaglandins A1, E1, A2, E2 and F2a were comparatively studied for their antiarrhythmic action using the model of strophanthin arrhythmia of narcotized cats. Infusions of prostaglandins A1, E2 and F2a in doses of 1-5 mug/kg/min for 5 min improved the arrhythmias in 63%, 83% and 81% of the animals, respectively, whereas prostaglandin A2 was effective in 44%, and prostaglandin E1 in only 10% of the cats. Prostaglandins A1 and E2 transiently established a sinus rhythm in 54 and 50%, and prostaglandin F2a in 18% of the animals. The injection of 12 mu9/kg prostaglandin F2a brought about improvement of arrhythmia in 70% of the animals, producing a transient sinus rhythm in 40%. With ajmaline as the standard substance in doses of 0.3 mg/kg/min for 5 min produced an antiarrhythmic effect in 50% of the animals, while injection of 1 mg/kg was effective in 60% of the animals. Effects on the vegetative nervous system are discussed as the possible action mechanism of the prostaglandins.
利用麻醉猫的毒毛花苷所致心律失常模型，对前列腺素A1、E1、A2、E2和F2α的抗心律失常作用进行了比较研究。以1 - 5微克/千克/分钟的剂量输注前列腺素A1、E2和F2α 5分钟，分别使63%、83%和81%的动物心律失常得到改善，而前列腺素A2对44%的动物有效，前列腺素E1仅对10%的猫有效。前列腺素A1和E2分别使54%和50%的动物短暂恢复窦性心律，前列腺素F2α使18%的动物恢复窦性心律。注射12微克/千克前列腺素F2α可使70%的动物心律失常得到改善，40%的动物出现短暂窦性心律。以阿吗灵作为标准物质，按0.3毫克/千克/分钟的剂量注射5分钟，可使50%的动物产生抗心律失常作用，注射1毫克/千克则使60%的动物有效。讨论了对自主神经系统的影响作为前列腺素可能的作用机制。
