男同性恋者患卡波西肉瘤的风险因素。

Risk factors for Kaposi's sarcoma in homosexual men.

作者信息

Marmor M, Friedman-Kien A E, Laubenstein L, Byrum R D, William D C, D'onofrio S, Dubin N

出版信息

Lancet. 1982 May 15;1(8281):1083-7. doi: 10.1016/s0140-6736(82)92275-9.

Abstract

An investigation of 20 homosexual men with histologically confirmed Kaposi's sarcoma and 40 controls revealed significant associations between Kaposi's sarcoma and use of a number of drugs (amyl nitrite, ethyl chloride, cocaine, phencyclidine, methaqualone, and amphetamine), history of mononucleosis, and sexual activity in the year before onset of the disease. Patients with Kaposi's sarcoma also reported substantially higher rates of sexually transmitted infections than did controls. Multivariate analysis indicated independent significant associations for amyl nitrite and sexual activity and showed use of phencyclidine, methaqualone, and ethyl chloride to be non-significant. Evaluated at the median exposure for patients, the analysis yielded risk-ratio estimates of 12.3 for amyl nitrite (95% confidence limits 4.2, 35.8) and 2.0 for sexual activity (95% confidence limits 1.3, 3.1).

摘要

对20名经组织学确诊为卡波西肉瘤的同性恋男性和40名对照者进行的一项调查显示，卡波西肉瘤与多种药物（亚硝酸戊酯、氯乙烷、可卡因、苯环己哌啶、甲喹酮和苯丙胺）的使用、单核细胞增多症病史以及疾病发作前一年的性活动之间存在显著关联。卡波西肉瘤患者报告的性传播感染率也显著高于对照者。多变量分析表明，亚硝酸戊酯和性活动存在独立的显著关联，而苯环己哌啶、甲喹酮和氯乙烷的使用则无显著意义。以患者的中位暴露量进行评估，分析得出亚硝酸戊酯的风险比估计值为12.3（95%置信区间4.2, 35.8），性活动的风险比估计值为2.0（95%置信区间1.3, 3.1）。