Binding of [3H]ADTN to rat striatal membranes.

Templeton W W, Woodruff G N

Biochem Pharmacol. 1982 Apr 15;31(8):1629-32. doi: 10.1016/0006-2952(82)90391-4.

The conformationally restricted dopamine analogue ADTN binds in a specific saturable manner to rat striatal membranes. Analysis of the data suggests a single binding site. Binding of [3H]ADTN is displaced by a wide range of dopamine agonists and antagonists (both typical and atypical). The potency of ADTN derivatives to displace [3H]ADTN correlates well with their activity as agonists in other tests both in vivo and in vitro.

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Biochem Pharmacol. 1982 Apr 15;31(8):1629-32. doi: 10.1016/0006-2952(82)90391-4.

Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics.

J Neurosci. 1982 Jul;2(7):895-906. doi: 10.1523/JNEUROSCI.02-07-00895.1982.

Ascorbic acid and membrane ageing: critical determinants of the in-vitro binding of [3H]ADTN to rat striatal tissue.

J Pharm Pharmacol. 1983 Nov;35(11):738-45. doi: 10.1111/j.2042-7158.1983.tb02881.x.

Kinetic and pharmacological profiles of the in vitro binding of the potent dopamine agonist [3H]N,N-dipropyl-5,6-dihydroxy-2-aminotetralin to rat striatal membranes.

Eur J Pharmacol. 1985 May 28;112(1):73-9. doi: 10.1016/0014-2999(85)90240-7.

Altered characteristics of striatal [3H]ADTN binding following substantia nigra lesions.

Eur J Pharmacol. 1982 Sep 10;83(1-2):61-7. doi: 10.1016/0014-2999(82)90286-2.

Eur J Pharmacol. 1979 Apr 15;55(2):137-42. doi: 10.1016/0014-2999(79)90385-6.

[3H] 2-Amino-6,7-dihydroxy 1,2,3,4-tetrahydronapthalene (ADTN): a potential specific dopamine receptor ligand.

Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):15-25.

Changes in (3H)-ADTN binding to microsomal and synaptic membrane fractions from rat striata following kainic acid lesions.

Biochem Pharmacol. 1980 Jun 15;29(12):1645-8. doi: 10.1016/0006-2952(80)90118-5.

Properties of dopamine agonist and antagonist binding sites in mammalian retina.

Brain Res. 1980 Aug 4;194(2):403-18. doi: 10.1016/0006-8993(80)91221-4.

S(-)DP-5,6-ADTN as an in vivo dopamine receptor ligand: relation between displacement by dopamine agonists and their pharmacological effects.

Naunyn Schmiedebergs Arch Pharmacol. 1986 Apr;332(4):338-45. doi: 10.1007/BF00500084.

引用本文的文献

A comparison of some of the properties of the [3H]-sulpiride binding site in soluble and native membrane preparations of dog striatum.

Br J Pharmacol. 1983 Jan;78(1):5-7. doi: 10.1111/j.1476-5381.1983.tb09355.x.

Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin.

Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):494-501. doi: 10.1007/BF00169305.

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Templeton W W, Woodruff G N

Biochem Pharmacol. 1982 Apr 15;31(8):1629-32. doi: 10.1016/0006-2952(82)90391-4.

相似文献

Binding of [3H]ADTN to rat striatal membranes.

Biochem Pharmacol. 1982 Apr 15;31(8):1629-32. doi: 10.1016/0006-2952(82)90391-4.

Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics.

J Neurosci. 1982 Jul;2(7):895-906. doi: 10.1523/JNEUROSCI.02-07-00895.1982.

Ascorbic acid and membrane ageing: critical determinants of the in-vitro binding of [3H]ADTN to rat striatal tissue.

J Pharm Pharmacol. 1983 Nov;35(11):738-45. doi: 10.1111/j.2042-7158.1983.tb02881.x.

Kinetic and pharmacological profiles of the in vitro binding of the potent dopamine agonist [3H]N,N-dipropyl-5,6-dihydroxy-2-aminotetralin to rat striatal membranes.

Eur J Pharmacol. 1985 May 28;112(1):73-9. doi: 10.1016/0014-2999(85)90240-7.

Altered characteristics of striatal [3H]ADTN binding following substantia nigra lesions.

Eur J Pharmacol. 1982 Sep 10;83(1-2):61-7. doi: 10.1016/0014-2999(82)90286-2.

Eur J Pharmacol. 1979 Apr 15;55(2):137-42. doi: 10.1016/0014-2999(79)90385-6.

[3H] 2-Amino-6,7-dihydroxy 1,2,3,4-tetrahydronapthalene (ADTN): a potential specific dopamine receptor ligand.

Res Commun Chem Pathol Pharmacol. 1978 Oct;22(1):15-25.

Changes in (3H)-ADTN binding to microsomal and synaptic membrane fractions from rat striata following kainic acid lesions.

Biochem Pharmacol. 1980 Jun 15;29(12):1645-8. doi: 10.1016/0006-2952(80)90118-5.

Properties of dopamine agonist and antagonist binding sites in mammalian retina.

Brain Res. 1980 Aug 4;194(2):403-18. doi: 10.1016/0006-8993(80)91221-4.

S(-)DP-5,6-ADTN as an in vivo dopamine receptor ligand: relation between displacement by dopamine agonists and their pharmacological effects.

Naunyn Schmiedebergs Arch Pharmacol. 1986 Apr;332(4):338-45. doi: 10.1007/BF00500084.

引用本文的文献

A comparison of some of the properties of the [3H]-sulpiride binding site in soluble and native membrane preparations of dog striatum.

Br J Pharmacol. 1983 Jan;78(1):5-7. doi: 10.1111/j.1476-5381.1983.tb09355.x.

Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin.

Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):494-501. doi: 10.1007/BF00169305.

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